Publications

Authors:

Conci, Simone; Cipriani, Federica; Donadon, Matteo; Marchitelli, Ivan; Ardito, Francesco; Famularo, Simone; Perri, Pasquale; Iaria, Maurizio; Ansaloni, Luca; Zanello, Matteo; La Barba, Giuliano; Patauner, Stefan; Pinotti, Enrico; Molfino, Sarah; Germani, Paola; Romano, Maurizio; Sciannamea, Ivano; Ferrari, Cecilia; Manzoni, Alberto; Troci, Albert; Fumagalli, Luca; Delvecchio, Antonella; Floridi, Antonio; Memeo, Riccardo; Chiarelli, Marco; Crespi, Michele; Zimmitti, Giuseppe; Griseri, Guido; Antonucci, Adelmo; Zanus, Giacomo; Tarchi, Paola; Baiocchi, Gian Luca; Zago, Mauro; Frena, Antonio; Ercolani, Giorgio; Jovine, Elio; Maestri, Marcello; Valle, Raffaele Dalla; Grazi, Gian Luca; Romano, Fabrizio; Giuliante, Felice; Torzilli, Guido; Aldrighetti, Luca; Ruzzenente, Andrea

Title:

Hepatectomy for Metabolic Associated Fatty Liver Disease (MAFLD) related HCC: Propensity case-matched analysis with viral- and alcohol-related HCC

Year:

2022

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

European Journal of Surgical Oncology

ISSN of journal:

0748-7983

N° Volume:

48

Number or Folder:

1

Page numbers:

103-112

Keyword:

Hepatectomy; Hepatocellular carcinoma; Liver resection; Metabolic associated fatty liver disease; Metabolic syndrome; NAFLD; Aged; Body Mass Index; Carcinoma, Hepatocellular; Comorbidity; Disease-Free Survival; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Liver Cirrhosis; Liver Diseases, Alcoholic; Liver Neoplasms; Male; Middle Aged; Neoplasms, Multiple Primary; Non-alcoholic Fatty Liver Disease; Propensity Score; Survival Rate; Tumor Burden; Hepatectomy

Short description of contents:

Background and aims: We investigated the clinical impact of the newly defined metabolic-associated fatty liver disease (MAFLD) in patients undergoing hepatectomy for HCC (MAFLD-HCC) comparing the characteristics and outcomes of patients with MAFLD-HCC to viral- and alcoholic-related HCC (HCV-HCC, HBV-HCC, A-HCC).Methods: A retrospective analysis of patients included in the He.RC.O.Le.S. Group registry was performed. The characteristics, short- and long-term outcomes of 1315 patients included were compared according to the study group before and after an exact propensity score match (PSM).Results: Among the whole study population, 264 (20.1%) had MAFLD-HCC, 205 (15.6%) had HBV-HCC, 671 (51.0%) had HCV-HCC and 175 (13.3%) had A-HCC. MAFLD-HCC patients had higher BMI (p < 0.001), Charlson Comorbidities Index (p < 0.001), size of tumour (p < 0.001), and presence of cirrhosis (p < 0.001). After PSM, the 90-day mortality and severe morbidity rates were 5.9% and 7.1% in MAFLD-HCC, 2.3% and 7.1% in HBV-HCC, 3.5% and 11.7% in HCV-HCC, and 1.2% and 8.2% in A-HCC (p = 0.061 and p = 0.447, respectively). The 5-year OS and RFS rates were 54.4% and 37.1% in MAFLD-HCC, 64.9% and 32.2% in HBV-HCC, 53.4% and 24.7% in HCV-HCC and 62.0% and 37.8% in A-HCC (p = 0.345 and p = 0.389, respectively). Cirrhosis, multiple tumours, size and satellitosis seems to be the independent predictors of OS.Conclusion: Hepatectomy for MAFLD-HCC seems to have a higher but acceptable operative risk. However, long-term outcomes seems to be related to clinical and pathological factors rather than aetiological risk factors. (C) 2021 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Product ID:

130575

Handle IRIS:

11562/1078662

Last Modified:

January 24, 2025

Bibliographic citation:

Conci, Simone; Cipriani, Federica; Donadon, Matteo; Marchitelli, Ivan; Ardito, Francesco; Famularo, Simone; Perri, Pasquale; Iaria, Maurizio; Ansaloni, Luca; Zanello, Matteo; La Barba, Giuliano; Patauner, Stefan; Pinotti, Enrico; Molfino, Sarah; Germani, Paola; Romano, Maurizio; Sciannamea, Ivano; Ferrari, Cecilia; Manzoni, Alberto; Troci, Albert; Fumagalli, Luca; Delvecchio, Antonella; Floridi, Antonio; Memeo, Riccardo; Chiarelli, Marco; Crespi, Michele; Zimmitti, Giuseppe; Griseri, Guido; Antonucci, Adelmo; Zanus, Giacomo; Tarchi, Paola; Baiocchi, Gian Luca; Zago, Mauro; Frena, Antonio; Ercolani, Giorgio; Jovine, Elio; Maestri, Marcello; Valle, Raffaele Dalla; Grazi, Gian Luca; Romano, Fabrizio; Giuliante, Felice; Torzilli, Guido; Aldrighetti, Luca; Ruzzenente, Andrea, Hepatectomy for Metabolic Associated Fatty Liver Disease (MAFLD) related HCC: Propensity case-matched analysis with viral- and alcohol-related HCC «European Journal of Surgical Oncology» , vol. 48 , n. 1 , 2022 , pp. 103-112

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