Publications

Authors:

Porcaro, Antonio Benito; Bianchi, Alberto; Gallina, Sebastian; Serafin, Emanuele; Mazzucato, Giovanni; Panunzio, Andrea; Tafuri, Alessandro; Montanaro, Francesca; Marafioti Patuzzo, Giulia; Baielli, Alberto; Artoni, Francesco; Vidiri, Stefano; Cianflone, Francesco; D'Aietti, Damiano; Brunelli, Matteo; Siracusano, Salvatore; Cerruto, Maria Angela; Antonelli, Alessandro

Title:

Positive independent association between preoperative endogenous testosterone density and tumor load density in surgical specimen of patients undergoing radical prostatectomy

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Urologia

ISSN of journal:

0391-5603

N° Volume:

91

Number or Folder:

1

Page numbers:

76-84

Keyword:

Prostate cancer; endogenous testosterone; percentage of biopsy positive cores density; radical prostatectomy; tumor load

Short description of contents:

Objective: To evaluate the influence of endogenous testosterone density (ETD) and tumor load density (TLD) in the surgical specimen of prostate cancer (PCa) patients. Methods: ETD was assessed as the ratio of endogenous testosterone (ET) to prostate volume (PV). TLD was calculated as the ratio of tumor load (TL) to prostate weight. Preoperative prostate-specific antigen relative densities (PSAD) and percentage of biopsy-positive cores (BPCD) were also assessed. The association of high TLD (above the first quartile) with clinical and pathological factors was assessed by the logistic regression model (univariate and multivariate analysis). Results: Between November 2014 and December 2019, ET was measured in 805 cases treated with radical prostatectomy (RP). Median (IQR) of ET and ETD was 412 (321.4-519 ng/dL) and 9.8 (6.8-14.4 ng/(dLxmL)) as well as for TL and TLD was 20 (10-30%) and 0.33 (0.17-0.58%/gr), respectively. As a result, high TLD was detected in 75% of cases. A positive independent association was found between high TLD and ETD. Accordingly, as ETD levels increased, the risk of detecting high TLD in the surgical specimen increased, regardless of PSAD and BPCD. Conclusions: At diagnosis of PCa, a positive independent association was found between ETD and risk of high TLD. Subjects with increasing ETD levels were more likely to have high TLD, associated with unfavorable pathology features. The positive association between ETD and TLD in the prostate microenvironment might adversely influence PCa's natural history.

Note:

Epub 2023 Aug 1

Product ID:

134963

Handle IRIS:

11562/1102086

Last Modified:

April 6, 2024

Bibliographic citation:

Porcaro, Antonio Benito; Bianchi, Alberto; Gallina, Sebastian; Serafin, Emanuele; Mazzucato, Giovanni; Panunzio, Andrea; Tafuri, Alessandro; Montanaro, Francesca; Marafioti Patuzzo, Giulia; Baielli, Alberto; Artoni, Francesco; Vidiri, Stefano; Cianflone, Francesco; D'Aietti, Damiano; Brunelli, Matteo; Siracusano, Salvatore; Cerruto, Maria Angela; Antonelli, Alessandro, Positive independent association between preoperative endogenous testosterone density and tumor load density in surgical specimen of patients undergoing radical prostatectomy «Urologia» , vol. 91 , n. 1 , 2024 , pp. 76-84

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