Publications

Authors:

Vergori, Alessandra; Cozzi-Lepri, Alessandro; Tavelli, Alessandro; Mazzotta, Valentina; Azzini, Anna Maria; Gagliardini, Roberta; Mastrorosa, Ilaria; Latini, Alessandra; Pellicanò, Giovanni; Taramasso, Lucia; Ceccherini-Silberstein, Francesca; Giannella, Maddalena; Tacconelli, Evelina; Marchetti, Giulia; Monforte, Antonella d'Arminio; Antinori, Andrea

Title:

SARS-CoV-2 mRNA vaccination and short-term changes in viral load and CD4/CD8 T cell counts in people living with HIV

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

International Journal of Infectious Diseases

ISSN of journal:

1201-9712

N° Volume:

144

Number or Folder:

July

Page numbers:

1-4

Keyword:

CD4 count; CD8 count; HIV; HIV RNA; mRNA SARS-CoV-2 vaccine; viro-immunological changes

Short description of contents:

Objectives: To investigate if SARS-CoV-2 mRNA vaccination has an impact on HIV-related viro-immunological parameters. Methods: PWH of the VAXICONA-ORCHESTRA cohort who received ≥1 dose of SARS-CoV-2 mRNA vaccine and for whom paired measures of immuno-virological markers [Viral Load (VL), CD4, CD8 count 1 month before and after a vaccine dose (VD)] were available, were included. Paired t-test and generalized estimating equation linear regression analyses were used to study changes over ± 1 month around the VD. Subgroup analyses were performed. Results: 510 PWH enrolled: median age 55 y (IQR 46-60), CD4 and CD8 count 489(287-719) and 790 (59-1104) cells/mm3. 81% received 3 VDs. After a median of 28 days (3-53) from VD, CD4 count increased by +15 cells/mm3 (SD ±129.7; p=0.001), CD8 by +12 (±250.5; p=0.199), VL decreased by -0.11 log10 (±0.88; p=0.001). Similar results were observed after restricting the analysis to viro-suppressed PWH, with CD4 ≤200/mm3, more than 6 months of ART before VD and after excluding previous COVID-19. Conclusions: A small significant increase in CD4 count and a negligible drop in HIV-RNA were observed. Our findings are consistent with the hypothesis that SARS-CoV-2 mRNA vaccine can prime CD4 T spike specific cells even in the more immuno-compromised PWH.

Note:

Epub 2024 Apr 19

Product ID:

139085

Handle IRIS:

11562/1125006

Last Modified:

June 16, 2024

Bibliographic citation:

Vergori, Alessandra; Cozzi-Lepri, Alessandro; Tavelli, Alessandro; Mazzotta, Valentina; Azzini, Anna Maria; Gagliardini, Roberta; Mastrorosa, Ilaria; Latini, Alessandra; Pellicanò, Giovanni; Taramasso, Lucia; Ceccherini-Silberstein, Francesca; Giannella, Maddalena; Tacconelli, Evelina; Marchetti, Giulia; Monforte, Antonella d'Arminio; Antinori, Andrea, SARS-CoV-2 mRNA vaccination and short-term changes in viral load and CD4/CD8 T cell counts in people living with HIV «International Journal of Infectious Diseases» , vol. 144 , n. July , 2024 , pp. 1-4

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