Publications

Authors:

Lamberti, Monica; Uccello, Rossella; Monaco, MARIA GRAZIA LOURDES; Muoio, Mariarosaria; Feola, Daniela; Sannolo, Nicola; Nienhaus, Albert; Chiodini, Paolo

Title:

Tuberculin Skin Test and Quantiferon test agreement and influencing factors in tuberculosis screening of healthcare workers: A systematic review and meta-analysis

Year:

2015

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY

ISSN of journal:

1745-6673

N° Volume:

10

Number or Folder:

1

:

London : Biomed Central

Page numbers:

1-13

Keyword:

Cohen's κ; Health surveillance; Healthcare workers; Meta-analysis; Quantiferon TB Gold; Tuberculin Skin Test; Tuberculosis

Short description of contents:

Objective: A systematic review and meta-analysis was conducted to evaluate the agreement between Tuberculin Skin Test (TST) and Quantiferon (QFT) in screening for tuberculosis (TB) infection among healthcare workers (HCWs) and to estimate associations between TST and QFT agreement and variables of interest, such as Bacillus Calmette-Guérin (BCG) vaccination and incidence of TB. Methods: Cross-sectional and longitudinal studies on HCWs, published in English until October 2013, comparing TST and QFT results, were selected. For each study Cohen’s κ value and a 95% confidence interval were calculated. Summary measures and indexes of heterogeneity between studies were calculated. Results: 29 studies were selected comprising a total of 11,434 HCWs. Cohen’s κ for agreement between TST and QFT for 24 of them was 0.28 (95% CI 0.22 to 0.35), with the best value in high TB incidence countries and the lowest rate of BCG vaccination. Conclusion: Currently, there is no gold standard for TB screening and the most-used diagnostic tools show low agreement. For evidence-based health surveillance in HCWs, occupational physicians need to consider a nu

Product ID:

141532

Handle IRIS:

11562/1141048

Last Modified:

October 10, 2024

Bibliographic citation:

Lamberti, Monica; Uccello, Rossella; Monaco, MARIA GRAZIA LOURDES; Muoio, Mariarosaria; Feola, Daniela; Sannolo, Nicola; Nienhaus, Albert; Chiodini, Paolo, Tuberculin Skin Test and Quantiferon test agreement and influencing factors in tuberculosis screening of healthcare workers: A systematic review and meta-analysis «JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY» , vol. 10 , n. 1 , 2015 , pp. 1-13

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