Publications

Authors:

Inguscio, Chiara Rita; Carton, Flavia; Cisterna, Barbara; Rizzi, Manuela; Boccafoschi, Francesca; Tabaracci, Gabriele; Malatesta, Manuela

Title:

Low ozone concentrations do not exert cytoprotective effects on tamoxifen-treated breast cancer cells in vitro

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

EUROPEAN JOURNAL OF HISTOCHEMISTRY

ISSN of journal:

2038-8306

N° Volume:

68

Number or Folder:

3

Page numbers:

1-7

Keyword:

MCF7 cells; oxidative stress; Nrf2; cell death; cell migration

Short description of contents:

Medical treatment with low ozone concentrations proved to exert therapeutic effects in various diseases by inducing a cytoprotective antioxidant response through the nuclear factor erythroid derived-like 2 (Nrf2) transcription factor pathway. Low ozone doses are increasingly administered to oncological patients as a complementary treatment to mitigate some adverse side-effects of antitumor treatments. However, a widespread concern exists about the possibility that the cytoprotective effect of Nrf2 activation may confer drug resistance to cancer cells or at least reduce the efficacy of antitumor agents. In this study, the effect of low ozone concentrations on tamoxifen-treated MCF7 human breast cancer cells has been investigated in vitro by histochemical and molecular techniques. Results demonstrated that cell viability, proliferation and migration were generally similar in tamoxifen-treated cells as in cells concomitantly treated with tamoxifen and ozone. Notably, low ozone concentrations were unable to overstimulate the antioxidant response through the Nfr2 pathway, thus excluding a possible ozone-driven cytoprotective effect that would lead to increased tumor cell survival during the antineoplastic treatment. These findings, though obtained in an in vitro model, support the hypothesis that low ozone concentrations do not interfere with the tamoxifen-induced effects on breast cancer cells.

Web page:

https://doi.org/10.4081/ejh.2024.4106

Product ID:

141787

Handle IRIS:

11562/1142586

Last Modified:

October 16, 2024

Bibliographic citation:

Inguscio, Chiara Rita; Carton, Flavia; Cisterna, Barbara; Rizzi, Manuela; Boccafoschi, Francesca; Tabaracci, Gabriele; Malatesta, Manuela, Low ozone concentrations do not exert cytoprotective effects on tamoxifen-treated breast cancer cells in vitro «EUROPEAN JOURNAL OF HISTOCHEMISTRY» , vol. 68 , n. 3 , 2024 , pp. 1-7

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