Publications

Authors:

Spagnol, Giulia; Bigardi, Sofia; Zorzi, Michela; Morotti, Matteo; Carollo, Massimo; Bruni, Giulia Micol; De Tommasi, Orazio; Tamagnini, Matteo; Xhindoli, Livia; Noventa, Marco; Tozzi, Roberto; Saccardi, Carlo; Marchetti, Matteo

Title:

Δ-Peritoneal Cancer Index (Δ-PCI) to Predict Complete Cytoreduction and Histopathological Response to Neoadjuvant Chemotherapy in Ovarian Cancer

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF CLINICAL MEDICINE

ISSN of journal:

2077-0383

N° Volume:

13

Number or Folder:

22

Page numbers:

13-25

Keyword:

chemotherapy response score; interval cytoreductive surgery; neoadjuvant chemotherapy; ovarian cancer; peritoneal cancer index

Short description of contents:

: Objectives: To analyze the role of PCI variation (Δ-PCI) before and after neoadjuvant chemotherapy (NACT) in an interval cytoreductive surgery (ICS) setting with the aim to propose a scoring model for predicting both complete cytoreduction and histopathologic response. Methods: A total of 50 consecutive patients who underwent ICS at our institution were prospectively collected between January-2020 and December-2023. PCI was assessed at exploratory surgery and at ICS. The clinical and histopathological response to NACT was determined by Δ-PCI and CRS. A cut-off value for Δ-PCI, to predict complete cytoreduction, histopathological response, and both together, was identified using a receiver operating characteristic (ROC) curve. The Kaplan-Meier test was used to define disease-free survival (DFS) based on the Δ-PCI cut-off value. Results: Complete cytoreduction was achieved in 82% of patients, with a median Δ-PCI score at ICS of 12 (range 7-29). The remaining 18% had a median Δ-PCI score at IDS of 8 (range 4-11). The best predictor of complete cytoreduction, histopathologic response CRS 3, and both was the Δ-PCI score, with an area under the curve (AUC) of 0.85 (0.73-0.96), 0.98 (0.94-1.00) and 0.88 (0.75-0.96), respectively; ROC curve analysis determined a Δ-PCI cut-off of 8, 17 and 15, respectively. Δ-PCI ≥ 15 as a predictor for both complete cytoreduction and histopathologic response CRS 3 with a median DFS of 26 months for Δ-PCI ≥ 15 versus 12 months for Δ-PCI < 15 (p = 0.02). Conclusions: Δ-PCI (cut-off ≥ 15) is a predictive model for complete cytoreduction, histological response CRS 3, and improved DFS.

Product ID:

142946

Handle IRIS:

11562/1146428

Last Modified:

December 20, 2024

Bibliographic citation:

Spagnol, Giulia; Bigardi, Sofia; Zorzi, Michela; Morotti, Matteo; Carollo, Massimo; Bruni, Giulia Micol; De Tommasi, Orazio; Tamagnini, Matteo; Xhindoli, Livia; Noventa, Marco; Tozzi, Roberto; Saccardi, Carlo; Marchetti, Matteo, Δ-Peritoneal Cancer Index (Δ-PCI) to Predict Complete Cytoreduction and Histopathological Response to Neoadjuvant Chemotherapy in Ovarian Cancer «JOURNAL OF CLINICAL MEDICINE» , vol. 13 , n. 22 , 2024 , pp. 13-25

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