Publications

Authors:

Pesonel, Elise; Laouénan, Cédric; Guiraud, Laetitia; Bourner, Josephine; Hoffmann, Isabelle; Molino, Diana; Tardivon, Coralie; Bachelet, Delphine; Mentré, France; Amstutz, Alain; Merson, Laura; Rojek, Amanda; Cervantes Gonzalez, Minerva; Antinori, Andrea; Castagna, Antonella; Nozza, Silvia; Pourcher, Valérie; Libois, Agnès; Dunning, Jake; Tacconelli, Evelina; Hites, Maya; De La Calle Prieto, Fernando; Horby, Peter; Yazdanpanah, Yazdan; Calmy, Alexandra; Lescure, F-Xavier; Olliaro, Piero

Title:

Clinical characterisation and outcomes of human clade IIb mpox virus disease - a European multicentre observational cohort study (MOSAIC)

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

Clinical Infectious Diseases

ISSN of journal:

1058-4838

N° Volume:

Online ahead of print

Number or Folder:

Jan 3

Page numbers:

1-1

Keyword:

Clade IIb; Lesion resolution; Mpox; Observational cohort; viral load

Short description of contents:

Background: The global mpox outbreak which started in May 2022 was caused by a novel clade IIb variant of the mpox virus (MPXV). It differed from the traditional Western and Central Africa disease in transmission patterns and clinical presentation. Methods: To address the need for detailed clinical and virologic data, we conducted an observational cohort study (MOSAIC) during May 2022-July 2023 in individuals with confirmed MPXV infection enrolled in six European Countries. Case-management decisions were left to the attending physician. Participants were monitored for up to six months for clinical signs/symptoms and clinical and virologic outcomes through hospital visits, phone interviews, and self-administered questionnaires. Outcomes included time-to-lesion resolution, clinical status, and virus clearance. Results: The 518 participants not receiving any specific treatment ("untreated") were diagnosed a median 5 days from symptom onset; 90% were managed as outpatients. Lesions were mostly cutaneous (88%) as and peri-genital (74%). By Day 14 from the first PCR-positive sample, 39% had resolved lesions. Time-to 95% unculturable virus was longest in cutaneous lesions (52 days). A putative systemic antiviral was available for 57 participants, 44% as in-patients, 34% and 58% had resolved lesions by D14 from the first PCR-positive sample and from treatment start, respectively. Time-to 95% unculturable virus was 60 days in skin and oropharynx. No death or recrudescence occurred by Day 180. Conclusion: MOSAIC provides comprehensive insights into the clinical and virologic characteristics of mpox caused by the clade IIb variant. The study forms the basis of clinical characterisation for ongoing mpox outbreaks.

Product ID:

143800

Handle IRIS:

11562/1149691

Last Modified:

March 30, 2025

Bibliographic citation:

Pesonel, Elise; Laouénan, Cédric; Guiraud, Laetitia; Bourner, Josephine; Hoffmann, Isabelle; Molino, Diana; Tardivon, Coralie; Bachelet, Delphine; Mentré, France; Amstutz, Alain; Merson, Laura; Rojek, Amanda; Cervantes Gonzalez, Minerva; Antinori, Andrea; Castagna, Antonella; Nozza, Silvia; Pourcher, Valérie; Libois, Agnès; Dunning, Jake; Tacconelli, Evelina; Hites, Maya; De La Calle Prieto, Fernando; Horby, Peter; Yazdanpanah, Yazdan; Calmy, Alexandra; Lescure, F-Xavier; Olliaro, Piero, Clinical characterisation and outcomes of human clade IIb mpox virus disease - a European multicentre observational cohort study (MOSAIC) «Clinical Infectious Diseases» , vol. Online ahead of print , n. Jan 3 , 2025 , pp. 1-1

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo