Publications

Authors:

Maio, Sara; Fasola, Salvatore; Marcon, Alessandro; Angino, Anna; Baldacci, Sandra; Bilò, Maria Beatrice; Bono, Roberto; Fois, Alessandro Giuseppe; La Grutta, Stefania; Marchetti, Pierpaolo; Sarno, Giuseppe; Squillacioti, Giulia; Stanisci, Ilaria; Pirina, Pietro; Tagliaferro, Sofia; Verlato, Giuseppe; Villani, Simona; Gariazzo, Claudio; Stafoggia, Massimo; Viegi, Giovanni

Title:

Relationship of long-term air pollution exposure with chronic obstructive pulmonary disease: an Italian multicentre observational study

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

ISSN of journal:

1351-0711

N° Volume:

82

Number or Folder:

1

:

BMJ / British Medical Journal Publishing Group:PO Box 299, London WC1H 9TD United Kingdom:011 44 20 73836270, EMAIL: subscriptions@bmjgroup.com, INTERNET: http://www.bmjpg.com/bmj, Fax: 011 44 20 73836402

Page numbers:

21-27

Keyword:

Air pollution; Cross-Sectional Studies; Environmental Exposure; Epidemiology; Respiratory System

Short description of contents:

Background Recent evidence showed that 50% of chronic obstructive pulmonary disease (COPD) may be attributable to air pollution. We aimed to investigate the association between long-term air pollution exposure and COPD symptoms/diagnosis in an Italian epidemiological study.Methods A total of 14 420 adults living in Ancona, Pavia, Pisa, Sassari, Turin and Verona were investigated in 2005-2011. Data on risk factors and health outcomes were collected by questionnaires; mean annual concentrations of particulate matters (PM) like PM10 and PM2.5 as well as NO2 and mean summer concentrations of O3 (mu g/m3) at residential level with a 1 km resolution (period 2013-2015) were obtained by machine learning techniques. The relationship of pollutant exposure and COPD prevalence was assessed by logistic regression models (single pollutant) and principal component logistic regression models (multipollutant) adjusting for sex, age, education level, smoking habits, season of interview, and city-specific climatic index and including a random intercept for cohorts.Results A 10 mu g/m3 increase of PM10, PM2.5 and NO2 exposure was related to COPD diagnosis and symptoms (OR 1.31, 95% CI 1.03 to 1.65 for PM2.5; OR 1.26, 95% CI 1.03 to 1.54 for PM10 and OR 1.07, 95% CI 1.00 to 1.15 for NO2) using a multipollutant approach. Similar results emerged for dyspnoea (OR 1.24, 95% CI 1.05 to 1.47 for PM2.5; OR 1.21, 95% CI 1.05 to 1.39 for PM10 and OR 1.06, 95% CI 1.01 to 1.11 for NO2). Associations between COPD symptoms and summer O3 were less clear. By multipollutant models, OR estimates were lower than those by single pollutant models.Conclusions Further evidence about the relationship between air pollution and respiratory effects in Italian adults was provided indicating PM as the main driver.

Product ID:

144568

Handle IRIS:

11562/1156789

Last Modified:

March 30, 2025

Bibliographic citation:

Maio, Sara; Fasola, Salvatore; Marcon, Alessandro; Angino, Anna; Baldacci, Sandra; Bilò, Maria Beatrice; Bono, Roberto; Fois, Alessandro Giuseppe; La Grutta, Stefania; Marchetti, Pierpaolo; Sarno, Giuseppe; Squillacioti, Giulia; Stanisci, Ilaria; Pirina, Pietro; Tagliaferro, Sofia; Verlato, Giuseppe; Villani, Simona; Gariazzo, Claudio; Stafoggia, Massimo; Viegi, Giovanni, Relationship of long-term air pollution exposure with chronic obstructive pulmonary disease: an Italian multicentre observational study «OCCUPATIONAL AND ENVIRONMENTAL MEDICINE» , vol. 82 , n. 1 , 2025 , pp. 21-27

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