Publications

Authors:

Liberati, C; Brigadoi, G; Gres, E; Barbieri, E; Cavagnero, F; Maestri, L; Trivellato, S; Zenere, A; De Pieri, M; Chiara, C Di; Mengato, D; Venturini, F; Canale, E De; Vecchio, C Del; Tessari, A; Tosoni, A; Zaggia, C; Contessa, C; Giaquinto, C; Carrara, E; Tacconelli, E; Amigoni, A; Donà, D

Title:

Revisiting Antimicrobial Stewardship in the Paediatric Intensive Care Unit: Insights from an Unconventional Approach

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Journal of Hospital Infection

ISSN of journal:

0195-6701

N° Volume:

160

Page numbers:

53-59

Keyword:

Antimicrobial stewardship; Handshake stewardship; Paediatric intensive care unit

Short description of contents:

Background: Patients admitted to the Paediatric Intensive Care Unit (PICU) constitute a high-risk group with a heightened likelihood of receiving inappropriate antimicrobial prescriptions. This study describes an Antimicrobial Stewardship Programme (ASP) in the PICU of a tertiary hospital in Italy. Method: A pre-post quasi experimental study was conducted between 01/01/2019 and 31/12/2022 in the PICU of the Department for Women's and Children's Health, University Hospital of Padua. The ASP intervention started in February 2021 by a multidisciplinary team using the "handshake" approach. The population included all patients admitted to the PICU. The primary outcome was antibiotic consumption measured as days of therapy administered (DOTs)/1000 patient-days. An interrupted time series analysis was used to assess the trend in antibiotic prescribing before and after the intervention. Results: 616 patients (episodes) were admitted in the pre-intervention phase (Jan 2019 - Jan 2021) and 602 patients in the post-intervention phase (Feb 2021 - Dec 2022). For overall antibiotic consumption, the ASP implementation resulted in a significant monthly decrease of 3.0% (p< 0.0001). Monthly reductions for higher consumption antibiotics were: meropenem 4.9% (p=0.009), glycopeptides 3.8% (p=0.014), piperacillin-tazobactam 4.8% (p=0.034). The consumption of third-generation cephalosporins and amikacin did not significantly vary. Conclusions: The ASP intervention was effective in reducing the consumption of antimicrobials in such a complex setting. These results show the importance of antimicrobial stewardship in the scenario of critically ill children.

Note:

Epub 2025 Mar 1

Product ID:

144587

Handle IRIS:

11562/1156871

Last Modified:

July 9, 2025

Bibliographic citation:

Liberati, C; Brigadoi, G; Gres, E; Barbieri, E; Cavagnero, F; Maestri, L; Trivellato, S; Zenere, A; De Pieri, M; Chiara, C Di; Mengato, D; Venturini, F; Canale, E De; Vecchio, C Del; Tessari, A; Tosoni, A; Zaggia, C; Contessa, C; Giaquinto, C; Carrara, E; Tacconelli, E; Amigoni, A; Donà, D, Revisiting Antimicrobial Stewardship in the Paediatric Intensive Care Unit: Insights from an Unconventional Approach «Journal of Hospital Infection» , vol. 160 , 2025 , pp. 53-59

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