Publications

Authors:

Garonzi, Chiara; Chinello, Matteo; Caddeo, Giulia; Bonetti, Elisa; Esposto, Maria Pia; Pezzella, Vincenza; Vitale, Virginia; Zaccaron, Ada; Sorrentino, Annarita; Gibellini, Davide; Cesaro, Simone

Title:

Invasive Fungal Infection by Scedosporium apiospermum with Cerebral Involvement in a Pediatric Patient Affected by Chronic Granulomatous Disease After Hematopoietic Cell Transplant

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

JOURNAL OF FUNGI

ISSN of journal:

2309-608X

N° Volume:

11

Number or Folder:

4

Page numbers:

1-10

Keyword:

Scedosporium apiospermum infection; allogeneic hematopoietic cell transplantation; chronic granulomatous disease; mycoses

Short description of contents:

: A 5-year-old boy affected by chronic granulomatous disease (CGD) underwent two allogeneic hematopoietic cell transplants (HCT) from the same unrelated donor. The first HCT was complicated by prolonged fever and primary graft failure. While fully aplastic, the patient developed a disseminated infection by Scedosporium apiospermum involving the knee and parasternal skin (day +34 and +40 post-HCT). The patient was treated with voriconazole and granulocyte transfusions followed by a second HCT 80 days after the first HCT. At day +105, the patient developed fever, headache, and altered level of consciousness associated with multiple bilateral cerebral abscesses at magnetic resonance imaging. The serum B-D-glucan test was positive. Micafungin was added to voriconazole. Despite an initial clinical improvement, the patient developed hydrocephalus. Scedosporium apiospermum was cultured from cerebrospinal fluid. Liposomal amphotericin B, instead of micafungin, was combined with voriconazole as salvage therapy. Unfortunately, the patient developed uncal herniation and died at day +193 from HCT. This case shows that the prognosis of scedosporiosis remains poor despite adequate antifungal treatment. Noteworthy, the B-D-Glucan test is confirmed useful as a non-invasive marker for early diagnosis and may help the differential diagnosis of mycoses.

Product ID:

145392

Handle IRIS:

11562/1160777

Last Modified:

May 11, 2025

Bibliographic citation:

Garonzi, Chiara; Chinello, Matteo; Caddeo, Giulia; Bonetti, Elisa; Esposto, Maria Pia; Pezzella, Vincenza; Vitale, Virginia; Zaccaron, Ada; Sorrentino, Annarita; Gibellini, Davide; Cesaro, Simone, Invasive Fungal Infection by Scedosporium apiospermum with Cerebral Involvement in a Pediatric Patient Affected by Chronic Granulomatous Disease After Hematopoietic Cell Transplant «JOURNAL OF FUNGI» , vol. 11 , n. 4 , 2025 , pp. 1-10

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