Publications

Authors:

Marastoni, Damiano; Colato, Elisa; Foschi, Matteo; Tamanti, Agnese; Ziccardi, Stefano; Eccher, Chiara; Crescenzo, Francesco; Bajrami, Albulena; Schiavi, Gian Marco; Camera, Valentina; Anni, Daniela; Virla, Federica; Guandalini, Maddalena; Turano, Ermanna; Pizzini, Francesca Benedetta; Montemezzi, Stefania; Bonetti, Bruno; Howell, Owain; Magliozzi, Roberta; Nicholas, Richard S; Scalfari, Antonio; Granziera, Cristina; Kappos, Ludwig; Calabrese, Massimiliano

Title:

Intrathecal Inflammatory Profile and Gray Matter Damage Predict Progression Independent of Relapse Activity in Early Multiple Sclerosis

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

NEUROLOGY® NEUROIMMUNOLOGY & NEUROINFLAMMATION

ISSN of journal:

2332-7812

N° Volume:

12

Number or Folder:

4

Page numbers:

1-14

Keyword:

LIGHT, DISABILITY,DEMYELINATION, PATHOGENESIS, IMPAIRMENT

Short description of contents:

Background and objectives: The objective of this study was to determine, at the time of diagnosis, a CSF and MRI profile of intrathecal compartmentalized inflammation predictive of progression independent of relapse activity (PIRA) in early relapsing-remitting multiple sclerosis (RRMS). Methods: This five-year prospective study included 80 treatment-naïve patients with RRMS enrolled at time of diagnosis. All patients underwent a lumbar puncture, regular neurologic evaluations including an Expanded Disability Status Scale (EDSS) assessment every 6 months, and an annual 3T brain MRI. PIRA was defined as having a confirmed disability progression independent of relapse activity. CSF levels of 68 inflammatory molecules were evaluated in combination with white matter and cortical lesion number (CLn) and volume, and regional gray matter thickness and volume. Results: During the follow-up, 23 patients with RRMS (28.8%) experienced PIRA. At diagnosis, participants with PIRA were older (44.0 ± 10.7 vs 37.4 ± 12.4, p = 0.017) and with more disability (median EDSS score [interquartile range] of 3 [range 2-4] for PIRA vs 1.5 [range 1-2] for no PIRA group, p < 0.001). Random forest selected LIGHT, CXCL13, sTNFR1, sTNFR2, CCL7, MIF, sIL6Rbeta, IL35, CCL2, and IFNβ as the CSF markers best associated with PIRA. sTNFR1 (hazard ratio [HR] 10.11 [2.61-39.10], p = 0.001), sTNFR2 (HR 5.05 [1.63-15.64], p = 0.005), and LIGHT (HR 1.79 [1.11-2.88], p = 0.018) were predictors of PIRA at regression analysis. Baseline thalamus volume (HR 0.98 [0.97-0.99], p = 0.005), middle frontal gyrus thickness (HR 0.05 [0.01-0.72], p = 0.028), and CLn (HR 1.15 [1.05-1.25], p = 0.003) were MRI predictors of PIRA. Discussion: A specific intrathecal inflammatory profile associated with TNF superfamily markers, CLn, and atrophy of several cortical and deep gray matter regions, assessed at time of diagnosis, is predictive of PIRA in early MS.

Note:

Epub 2025 May 1

Product ID:

145490

Handle IRIS:

11562/1161276

Last Modified:

May 17, 2025

Bibliographic citation:

Marastoni, Damiano; Colato, Elisa; Foschi, Matteo; Tamanti, Agnese; Ziccardi, Stefano; Eccher, Chiara; Crescenzo, Francesco; Bajrami, Albulena; Schiavi, Gian Marco; Camera, Valentina; Anni, Daniela; Virla, Federica; Guandalini, Maddalena; Turano, Ermanna; Pizzini, Francesca Benedetta; Montemezzi, Stefania; Bonetti, Bruno; Howell, Owain; Magliozzi, Roberta; Nicholas, Richard S; Scalfari, Antonio; Granziera, Cristina; Kappos, Ludwig; Calabrese, Massimiliano, Intrathecal Inflammatory Profile and Gray Matter Damage Predict Progression Independent of Relapse Activity in Early Multiple Sclerosis «NEUROLOGY® NEUROIMMUNOLOGY & NEUROINFLAMMATION» , vol. 12 , n. 4 , 2025 , pp. 1-14

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