Publications

Authors:

Bernardotto, Simone; Colusso, Elena; Calogero, Ylenia; Barker, Ilona; Franceschinis, Erica; Realdon, Nicola; Schiavon, Elisa; Stocco, Martina; Barbon, Tommaso; Rancan, Marzio; Martucci, Alessandro; Morpurgo, Margherita

Title:

Dissecting the contributions of composition and mesostructure on the release of thymol from silica-based mesopowders

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

ISSN of journal:

1773-2247

N° Volume:

110

Page numbers:

-----

Keyword:

Mesoporous powders; Controlled release; Thymol; Soft acaricide; Sol-gel silica

Short description of contents:

In pharmaceutics, mesoporous silica (MS)- based powders are used as high capacity sorbents for active agents, sometimes with controlled release properties. In literature, MS powder-adsorbed substances display faster or slower release compared to unformulated compounds. In order to understand this controversial phenomenon, we carried out a comprehensive study by investigating the behavior of thymol (TH, a model compound with acaricide properties against the Varroa destructor bee parasite) in different conditions, as a pure powder and when adsorbed onto four silica-based mesopowders from commercial (Sil-Sol 6035 (R), Neusilin US2 (R), Silica Gel 60737 (R)) and synthetic (MCM-41) origin, and characterized by different chemical composition and nano/mesostructure. All MS-powders displayed high TH loading capacity (between 0.35 and 0.72 g/g SiO2), related to their mesopore volume. Stabilization of physisorbed TH in amorphous form was achieved by all except Neusilin US2 (R). Adsorption onto MCM-41 and SiliSol (R) or Silica Gel 60737 (R) led to tenfold and twofold reduction of sublimation rate at 33 degrees C (the average beehive temperature during treatment), respectively. Adsorption onto the three retentive MS-powders also reduced the energy of activation (Ea) of TH sublimation, providing explanation on the controversial effects on the release of bioactive agents adsorbed onto MS powders described by the literature. In field applications, the effect exerted by the retentive powders should permit to cover the entire Varroa reproduction cycle by a single administration. Reduction of the sublimation Ea brings the additional advantage of reducing sensitivity of the sublimation process to the environment temperature fluctuations.

Product ID:

146389

Handle IRIS:

11562/1165350

Last Modified:

June 27, 2025

Bibliographic citation:

Bernardotto, Simone; Colusso, Elena; Calogero, Ylenia; Barker, Ilona; Franceschinis, Erica; Realdon, Nicola; Schiavon, Elisa; Stocco, Martina; Barbon, Tommaso; Rancan, Marzio; Martucci, Alessandro; Morpurgo, Margherita, Dissecting the contributions of composition and mesostructure on the release of thymol from silica-based mesopowders «JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY» , vol. 110 , 2025 , pp. -----

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo