Publications

Authors:

Magnano, Greta Camilla; Glerean, Martina; Dall'Acqua, Stefano; Abrami, Michela; Filon, Francesca Larese; Carton, Flavia; Malatesta, Manuela; Calderan, Laura; Galvan, Andrea; Voinovich, Dario; Hasa, Dritan

Title:

Enhanced transdermal delivery of [6]-Gingerol via Co-Administration of Acmella oleracea and Zingiber officinale lipophilic extracts

Year:

2026

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

INTERNATIONAL JOURNAL OF PHARMACEUTICS

ISSN of journal:

0378-5173

N° Volume:

695

Page numbers:

1-12

Keyword:

Acmella oleracea; Galenic formulation; Natural products; Spilanthol; Zingiber officinale; [6]-gingerol

Short description of contents:

Acmella oleracea and Zingiber officinale (ginger) are two plants of great interest due to their antioxidant, antimicrobial, and especially anti-inflammatory properties. These effects are mainly attributed to the presence of bioactive compounds such as spilanthol in Acmella oleracea and [6]-gingerol in Zingiber officinale. However, [6]-gingerol is primarily metabolized at the gastrointestinal and hepatic levels after oral administration, limiting its systemic bioavailability and effectiveness. In this study, a cream formulation containing both extracts was prepared using a preformed commercial transdermal vehicle and characterised through rheological studies. The ex vivo skin permeation of spilanthol and [6]-gingerol was evaluated using Franz diffusion cells. Results showed that the presence of Acmella oleracea lipophilic extract promoted the permeation of [6]-gingerol. Moreover, no histological alterations were observed in explanted human skin after transdermal application in a fluidic dynamic system. Based on these findings, topical administration of a formulation containing both Zingiber officinale and Acmella oleracea lipophilic extracts appears to be a promising strategy for enhancing the skin permeability of the active ingredients and, specifically for [6]-gingerol, avoiding its transformation in the gastrointestinal tract.

Web page:

https://doi.org/10.1016/j.ijpharm.2026.126745

Product ID:

150435

Handle IRIS:

11562/1186747

Last Modified:

March 21, 2026

Bibliographic citation:

Magnano, Greta Camilla; Glerean, Martina; Dall'Acqua, Stefano; Abrami, Michela; Filon, Francesca Larese; Carton, Flavia; Malatesta, Manuela; Calderan, Laura; Galvan, Andrea; Voinovich, Dario; Hasa, Dritan, Enhanced transdermal delivery of [6]-Gingerol via Co-Administration of Acmella oleracea and Zingiber officinale lipophilic extracts «INTERNATIONAL JOURNAL OF PHARMACEUTICS» , vol. 695 , 2026 , pp. 1-12

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