Publications

Authors:

Pasini, F; Verlato, G; Durante, E; de Manzoni, G; Valduga, F; Accordini, S; Pedrazzani, C; Terzi, A; Pelosi, G

Title:

Persistent excess mortality from lung cancer in patients with stage I non-small-cell lung cancer, disease-free after 5 years

Year:

2003

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

British Journal of Cancer

ISSN of journal:

0007-0920

N° Volume:

88

Number or Folder:

11

Page numbers:

1666-1668

Keyword:

non-small-cell lung cancer, long-term survival, standardised incidence ratio, standardised mortality ratio

Short description of contents:

Among patients with non-small-cell lung cancer (NSCLC), those with pathological stage I have the best expectation of survival; however, survival is reduced to less than 50% in the long term. At present, it is unclear when patients can be reasonably defined as cured, and if they experience a higher incidence of malignant/nonmalignant diseases and a lower expectation of survival than the general population. A total of 134 stage I NSCLC patients, who had undergone resection at the Thoracic Surgery Unit of the General Hospital of Verona (north-eastern Italy) from October 1987 to December 1993, were still disease-free at 5 years. These subjects were further followed up, and morbidity and mortality rates were compared with those recorded in the general population of the same geographical area. The standardised incidence ratios (SIRs) for all malignancies and for lung cancer were higher than expected (2.39, 95% CI=1.6-3.5, P<0.001; 10.1, 95% CI=6.2-15.6, P<0.0001, respectively). The standardised mortality ratio (SMR) was also significantly increased (1.73, 95% CI=1.1-2.6, P=0.013). The excess mortality could be entirely explained by an increase in mortality from lung cancer (5.7, 95% CI=2.8-10.1, P<0.0001). This study shows that patients, resected for pathological stage I NSCLC and tumour-free after 5 years, have a higher incidence of new lung cancer compared with the general population, which in turn determines an excess in all-cause mortality in the following years.

Product ID:

22385

Handle IRIS:

11562/303027

Deposited On:

July 25, 2007

Last Modified:

November 15, 2022

Bibliographic citation:

Pasini, F; Verlato, G; Durante, E; de Manzoni, G; Valduga, F; Accordini, S; Pedrazzani, C; Terzi, A; Pelosi, G, Persistent excess mortality from lung cancer in patients with stage I non-small-cell lung cancer, disease-free after 5 years «British Journal of Cancer» , vol. 88 , n. 11 , 2003 , pp. 1666-1668

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