Publications

Authors:

Manganotti, P.; Brigo, F.; Zoccatelli, Giada; Alessandrini, Franco; Pizzini, Francesca; Beltramello, Alberto; Storti, Silvia Francesca; Formaggio, E.; Fiaschi, Antonio; Bongiovanni, Luigi Giuseppe

Title:

Highly focal BOLD activation on functional MRI in a patient with progressive myoclonic epilepsy and diffuse giant somatosensory evoked potentials.

Year:

2011

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

EPILEPSY & BEHAVIOR

ISSN of journal:

1525-5050

N° Volume:

20

Number or Folder:

3

Page numbers:

579-582

Keyword:

Functional magnetic resonance imaging; Progressive myoclonic epilepsy; Somatosensory evoked potentials

Short description of contents:

We analyzed the effect of afferent input on patterns of brain electrical activation in a 31-year-old man with progressive myoclonic epilepsy (PME) by measuring the somatosensory evoked potential (SSEP) amplitude at the scalp after median nerve stimulation and examining the changes in the functional magnetic resonance imaging blood oxygen level-dependent (fMRI BOLD) signal. High-amplitude SSEPs were elicited at the wrist in association with highly focal BOLD activation of the contralateral sensorimotor areas. By contrast, no diffuse activation of either the frontal or the posterior parietal cortical areas was observed, as seen in previously recorded data on SSEPs from a healthy control group. The highly focal BOLD activation in this patient suggests that cortex hyperexcitability might be limited to the sensorimotor cortex in PME. The combined EEG-fMRI findings highlight a dissociation between BOLD activation and neurophysiological findings.

Product ID:

59923

Handle IRIS:

11562/348768

Deposited On:

March 24, 2011

Last Modified:

November 13, 2022

Bibliographic citation:

Manganotti, P.; Brigo, F.; Zoccatelli, Giada; Alessandrini, Franco; Pizzini, Francesca; Beltramello, Alberto; Storti, Silvia Francesca; Formaggio, E.; Fiaschi, Antonio; Bongiovanni, Luigi Giuseppe, Highly focal BOLD activation on functional MRI in a patient with progressive myoclonic epilepsy and diffuse giant somatosensory evoked potentials. «EPILEPSY & BEHAVIOR» , vol. 20 , n. 3 , 2011 , pp. 579-582

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