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Adverse events and adverse drug reactions in hospital observed by nurses: prospective analysis of 4608 patients  (2010)

Authors:
Opri, S.; Leone, Roberto; Moretti, Ugo; Conforti, Anita; D'Incau, P.; Magro, Lara; Smerghetto, M.; Velo, Giampaolo
Title:
Adverse events and adverse drug reactions in hospital observed by nurses: prospective analysis of 4608 patients
Year:
2010
Type of item:
Contributo in atti di convegno
Tipologia ANVUR:
Contributo in Atti di convegno
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
Drug Safety
ISSN of journal:
0114-5916
N° Volume:
33
Number or Folder:
10
Congresso:
10th ISoP Annual Meeting
Place:
Accra, Ghana
Period:
3-6 november 2010
:
ADIS
Publisher:
ADIS
Page numbers:
922-923
Keyword:
Adverse drug reactions; inpatients; nurses
Short description of contents:
Purpose: The aim of this study was to describe the pattern of adverse drug reaction (ADR) reports sent by Italian nurses after the enactment of the law involving them in the pharmacovigilance system. We also compared the quantity and quality of reports by nurses with those of reports by hospital physicians sent in the same period. Methods: We analysed the reports sent to the Italian pharmacovigilance database by nurses from January 2004 to December 2010. Only reports with ADRs causality assessment defined as definite, probable or possible were included in the analysis. The nurses’ reports were compared with those sent by hospital physicians in the same period. We excluded from this analysis reports associated with vaccines. Results: A total number of 1403 reports by nurses have been evaluated. The percentage of nurses’ reports of ADRs, which were serious, were 22.9% lower than the 44.9% of reports by physicians, whereas the proportion of probable ADR reports were higher among nurses than hospital physicians (76% vs 67%). Nurses put more emphasis than physicians on application site disorders (log OR = 0.91, 95%CI = 0.55–1.27), skin reactions (log OR = 0.81, 95%CI = 0.70–0.92) and nervous system reactions (log OR = 0.28, 95%CI = 0.11–0.44), whereas physicians more frequently report blood, platelet and liver disorders. Six drugs are present in both the top 10 drugs reported by nurses and hospital doctors. Conclusion: This study gives evidence for the potential capacity of nurses to improve the detection of ADRs. Copyright © 2012 John Wiley & Sons, Ltd.
Product ID:
61372
Handle IRIS:
11562/360252
Deposited On:
August 9, 2011
Last Modified:
May 11, 2021
Bibliographic citation:
Opri, S.; Leone, Roberto; Moretti, Ugo; Conforti, Anita; D'Incau, P.; Magro, Lara; Smerghetto, M.; Velo, Giampaolo, Adverse events and adverse drug reactions in hospital observed by nurses: prospective analysis of 4608 patients in «Drug Safety» vol. 33 n. 10 ADISProceedings of "10th ISoP Annual Meeting" , Accra, Ghana , 3-6 november 2010 , 2010pp. 922-923

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