Publications

Authors:

Bellani, Marcella; Perlini, Cinzia; Ferro, Adele; Cerruti, Stefania; Dusi, Nicola; Rambaldelli, Gianluca; Isola, M.; Cerini, Roberto; Andreone, Nicola; Balestrieri, M.; POZZI MUCELLI, Roberto; Tansella, Michele; Brambilla, P.

Title:

White matter microstructure alterations in bipolar disorder

Year:

2012

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Functional Neurology

ISSN of journal:

0393-5264

N° Volume:

27

Number or Folder:

1

Page numbers:

29-34

Keyword:

bipolar disorder; white matter; diffusion weighted imaging (DWI)

Short description of contents:

Genetic, neuropathologic and magnetic resonance imaging (MRI) findings support diffuse white matter cytoarchitecture disruption in bipolar disorder. In this study, diffusion weighted imaging (DWI) was applied to study cortical white matter microstructure organisation in 24 patients with DSM-IV bipolar disorder and 35 matched normal controls. DWI images were obtained using a 1.5 Tesla scanner and apparent diffusion coefficient (ADC) values were determined over regions of interest placed, bilaterally, in the frontal, temporal, parietal, and occipital white matter. Significantly increased ADC values were found in bipolar patients with respect to normal controls in right temporal lobe, left parietal lobe, and bilateral occipital lobes. ADC values did not associate significantly with age or with clinical variables (p>0.05). Diffuse cortical white matter alterations on DWI in bipolar disorder denote widespread disruption of white matter integrity and may be due to alterations of myelination and/or axonal integrity

Product ID:

69203

Handle IRIS:

11562/389551

Deposited On:

July 5, 2012

Last Modified:

November 15, 2022

Bibliographic citation:

Bellani, Marcella; Perlini, Cinzia; Ferro, Adele; Cerruti, Stefania; Dusi, Nicola; Rambaldelli, Gianluca; Isola, M.; Cerini, Roberto; Andreone, Nicola; Balestrieri, M.; POZZI MUCELLI, Roberto; Tansella, Michele; Brambilla, P., White matter microstructure alterations in bipolar disorder «Functional Neurology» , vol. 27 , n. 1 , 2012 , pp. 29-34

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