Publications

Authors:

Guglielmetti, L; Conti, Michela; Cazzadori, Angelo Antonio; LO CASCIO, Giuliana; Sorrentino, A; Concia, Ercole

Title:

Diagnostic sensitivity of QuantiFERON-TB Gold In-Tube and tuberculin skin test in active tuberculosis: influence of immunocompromission and radiological extent of disease

Year:

2012

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Italiano

Referee:

No

Name of journal:

Le infezioni in medicina

ISSN of journal:

1124-9390

N° Volume:

20

Number or Folder:

1

Page numbers:

16-24

Keyword:

Tuberculosis (TB); tuberculin skin test (TST); QuantiFERON-TB Gold In-Tube (QFT-IT)

Short description of contents:

Tuberculosis (TB) is a pathology whose control is still unsatisfactory at global level. Traditional diagnostic techniques for active TB diagnosis are inadequate: the diagnostic gold standard is the cultural exam which suffers from lengthy processing and requires highly specialized laboratories. This study analyzed the diagnostic sensitivity of the tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFT-IT) in 135 active, microbiologically confirmed TB cases. Sensitivity was 76% for both tests and reached cumulative levels close to 90%. QFT-IT revealed a statistically higher sensitivity than TST in a group of patients affected by various causes of immunosuppression, but was less sensitive in subjects with low levels of circulating CD4+ cells. The number of circulating CD4+ cells showed a direct correlation with the stimulated IFN-gamma production. QFT-IT also demonstrated a decreased IFN-gamma production, with a significant sensitivity reduction, in patients affected by advanced forms of pulmonary TB.

Product ID:

66928

Handle IRIS:

11562/397138

Deposited On:

April 30, 2014

Last Modified:

November 11, 2022

Bibliographic citation:

Guglielmetti, L; Conti, Michela; Cazzadori, Angelo Antonio; LO CASCIO, Giuliana; Sorrentino, A; Concia, Ercole, Diagnostic sensitivity of QuantiFERON-TB Gold In-Tube and tuberculin skin test in active tuberculosis: influence of immunocompromission and radiological extent of disease «Le infezioni in medicina» , vol. 20 , n. 1 , 2012 , pp. 16-24

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