Publications

Authors:

Zanoni, A; Verlato, Giuseppe; Giacopuzzi, Simone; Weindelmayer, J; Casella, F; Pasini, Felice; Zhao, E; DE MANZONI, Giovanni

Title:

Neoadjuvant Concurrent Chemoradiotherapy for Locally Advanced Esophageal Cancer in a Single High-Volume Center.

Year:

2013

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

ANNALS OF SURGICAL ONCOLOGY

ISSN of journal:

1068-9265

N° Volume:

20

Number or Folder:

6

Page numbers:

1993-1999

Keyword:

Esophageal Cancer; squamous cell carcinoma; adenocarcinoma; Neoadjuvant radiochemotherapy

Short description of contents:

Background. Neoadjuvant chemoradiotherapy (CRT) is now considered the standard of care bymany centers in the treatment of both squamous cell carcinoma (SCC) and adenocarcinoma of the esophagus. This study evaluates the effectiveness of a neoadjuvant CRT protocol, as regards pathological complete response (pCR) rate and long-term survival.Methods. From 2003 to 2011, at Upper G.I. Surgery Division of Verona University, 155 consecutive patients with locally advanced esophageal cancers (90 SCC, 65 adenocarcinoma) were treated with a single protocol of neoadjuvant CRT (docetaxel, cisplatin, and 5-fluorouracil with 50.4 Gy of concurrent radiotherapy). Response to CRT was evaluated through percentage of pathological complete response (pCR or ypT0N0), overall (OS) and disease-related survival (DRS), and pattern of relapse.Results. One hundred thirty-one patients (84.5 %) underwent surgery. Radical resection (R0) was achieved in 123 patients (79.3 %), and pCR in 65 (41.9 %). Postoperative mortality was 0.7 % (one case). Five-year OS and DRS were respectively 43 and 49 % in the entire cohort, 52 and 59 % in R0 cases, and 72 and 81 % in pCR cases. Survival did not significantly differ between SCC and adenocarcinoma, except for pCR cases. Forty-nine patients suffered from relapse, which was mainly systemic in adenocarcinoma. Only three out of 26 pCR patients with previous adenocarcinoma developed relapse, always systemic.Conclusions. This study suggests that patients treated with the present protocol achieve good survival and high pCR rate. Further research is necessary to evaluate whether surgery on demand is feasible in selected patients, such as pCR patients with adenocarcinoma.

Product ID:

81323

Handle IRIS:

11562/495153

Deposited On:

May 15, 2014

Last Modified:

June 6, 2023

Bibliographic citation:

Zanoni, A; Verlato, Giuseppe; Giacopuzzi, Simone; Weindelmayer, J; Casella, F; Pasini, Felice; Zhao, E; DE MANZONI, Giovanni, Neoadjuvant Concurrent Chemoradiotherapy for Locally Advanced Esophageal Cancer in a Single High-Volume Center. «ANNALS OF SURGICAL ONCOLOGY» , vol. 20 , n. 6 , 2013 , pp. 1993-1999

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