Publications

Authors:

Decimo, Ilaria; Fumagalli, Guido Francesco; Berton, Valeria; Krampera, Mauro; Bifari, Francesco

Title:

Meninges: from protective membrane to stem cell niche

Year:

2012

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

AMERICAN JOURNAL OF STEM CELLS

ISSN of journal:

2160-4150

N° Volume:

2

Number or Folder:

1

Page numbers:

92-105

Keyword:

Meninges; leptomeninges; arachnoid mater; pia mater; corticogenesis; neurogenesis; neural stem cells; neural progenitors; stem cell niche

Short description of contents:

Meninges are a three tissue membranes primarily known as coverings of the brain. More in depth studies on meningeal function and ultrastructure have recently changed the view of meninges as merely protective membrane. Accurate evaluation of the anatomical distribution in the CNS reveals that meninges largely penetrate inside the neural tissue. Meninges enter the CNS by projecting between structures, in the stroma of choroid plexus and form the perivascular space (Virchow-Robin) of every parenchymal vessel. Thus, meninges may modulate most of the physiological and pathological events of the CNS throughout the life. Meninges are present since the very early embryonic stages of cortical development and appear to be necessary for normal corticogenesis and brain structures formation. In adulthood meninges contribute to neural tissue homeostasis by secreting several trophic factors including FGF2 and SDF-1. Recently, for the first time, we have identified the presence of a stem cell population with neural differentiation potential in meninges. In addition, we and other groups have further described in meninges the presence of injury responsive neural precursors. In this review we will give a comprehensive view of meninges and their multiple roles in the context of a functional network with the neural tissue. We will highlight the current literature on the developmental feature of meninges and their role in cortical development. Moreover, we will elucidate the anatomical distribution of the meninges and their trophic properties in adult CNS. Finally, we will emphasize recent evidences suggesting the potential role of meninges as stem cell niche harbouring endogenous precursors that can be activated by injury and are able to contribute to CNS parenchymal reaction (AJSC1205003)

Product ID:

76045

Handle IRIS:

11562/506552

Last Modified:

November 14, 2022

Bibliographic citation:

Decimo, Ilaria; Fumagalli, Guido Francesco; Berton, Valeria; Krampera, Mauro; Bifari, Francesco, Meninges: from protective membrane to stem cell niche «AMERICAN JOURNAL OF STEM CELLS» , vol. 2 , n. 1 , 2012 , pp. 92-105

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