Publications

Hairy cell leukemia in kidney transplantation: lesson from a rare disorder.  (2013)

Authors:
Vinante, Fabrizio; Tomei, Paola; Zaza, Gianluigi; Zamo', Alberto; Lupo, Antonio
Title:
Hairy cell leukemia in kidney transplantation: lesson from a rare disorder.
Year:
2013
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
Elettronico
Referee:
Name of journal:
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
ISSN of journal:
2162-3619
N° Volume:
2
Number or Folder:
22
Page numbers:
1-5
Keyword:
Hairy cell leukemia; Kidney transplantation; Calcineurin inhibitors
Short description of contents:
We report here on the diagnosis and successful treatment of a case of hairy cell leukemia (HCL) that arose 15 years after kidney transplantation in a 51-year-old patient. As soon as the diagnosis was made, HCL was treated with 2-CDA, obtaining complete hematological remission. Immunosuppression with the calcineurin inhibitor cyclosporin was maintained, and the graft was preserved. In kidney transplant recipients supported with immunosuppressive drugs, post-transplant lymphoproliferative diseases (PTLDs) are frequent and typically related to immunosuppression via a loss of control of infectious/EBV-related proliferative stimuli. To date, HCL has not been considered among PTLDs. Recently, however, the oncogenic mutation V600E of the BRAF protein kinase has been found to be a hallmark of HCL, and calcineurin inhibitors have been shown to interfere with signaling downstream of V600E BRAF early on by counteracting senescence-associated mechanisms that protect against the oncogenic potential of the mutated kinase. Such a biochemical link between the oncogene-dependent signaling and calcineurin inhibitor activities suggests that HCL in transplanted patients might be a peculiar type of PTLD based on the presence of a specific mutation. This mechanism might also be involved in other neoplasias bearing the same or similar mutations, such as melanoma and non-melanoma skin cancer.
Web page:
http://ehoonline.biomedcentral.com/articles/10.1186/2162-3619-2-22
Product ID:
77834
Handle IRIS:
11562/613751
Deposited On:
September 25, 2013
Last Modified:
November 14, 2022
Bibliographic citation:
Vinante, Fabrizio; Tomei, Paola; Zaza, Gianluigi; Zamo', Alberto; Lupo, Antonio, Hairy cell leukemia in kidney transplantation: lesson from a rare disorder. «EXPERIMENTAL HEMATOLOGY & ONCOLOGY» , vol. 2 , n. 222013pp. 1-5

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

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