Publications

Authors:

Eccher, Albino; Lombardini, Letizia; Girolami, Ilaria; Puoti, Francesca; Zaza, Gianluigi; Gambaro, Giovanni; Carraro, Amedeo; Valotto, Giovanni; Cima, Luca; Novelli, Luca; Neil, Desley; Montin, Umberto; Scarpa, Aldo; Brunelli, Matteo; Nanni Costa, Alessandro; D'Errico, Antonia

Title:

How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network

Year:

2019

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

JN. JOURNAL OF NEPHROLOGY

ISSN of journal:

1121-8428

N° Volume:

32

Number or Folder:

2

:

Wichtig Editore:Via Friuli 72 74, I 20135 Milan Italy:011 39 02 5455122, 011 39 2 55195443, EMAIL: info@wichtig-publisher.com, INTERNET: http://www.wichtig-publisher.com, Fax: 011 39 2 55195971

Page numbers:

323-330

Keyword:

Donor evaluation; Donor with malignancy; Neoplastic transmission; Risk assessment; Transplantation

Short description of contents:

Guidelines for donor selection have changed to expand the donor pool, considering potential donors affected by a neoplasm. Aim of this retrospective study is to look at the use of organs from donors with a current or history of neoplasm within the Italian Transplant Network. Data, collected and validated by Italian National Health Institute for the time interval 2006-2015, have been reviewed retrospectively by mean of multivariable pivot tables. Donors with neoplasia represented about 5% of all donors, resulting in about 4% of all transplants. Donors presented a benign neoplasm in 29.08% of cases, a malignancy with variable risk of transmission in 69.75% while in 1.34% the nature of neoplasm could not be assessed. Considering all procedures, rate of transmission of a malignancy was 0.03% (10 cases) of all 29858 transplants of the time interval. Notably, cases of transmission were not from donors of this pool, but from donors that, according to our protocols, had no elements of suspect at time of donation. As recipient safety is always the priority and as guidelines have set exclusion criteria for donors with some specific types of malignancy, these results show that use of this type of donors is safe and improve organ pool. Furthermore represent basis for improvement and standardization of donor assessment protocols suggesting that efforts in data collection systems, to produce complete and homogeneous data, are mandatory.

Product ID:

105928

Handle IRIS:

11562/989662

Last Modified:

November 15, 2022

Bibliographic citation:

Eccher, Albino; Lombardini, Letizia; Girolami, Ilaria; Puoti, Francesca; Zaza, Gianluigi; Gambaro, Giovanni; Carraro, Amedeo; Valotto, Giovanni; Cima, Luca; Novelli, Luca; Neil, Desley; Montin, Umberto; Scarpa, Aldo; Brunelli, Matteo; Nanni Costa, Alessandro; D'Errico, Antonia, How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network «JN. JOURNAL OF NEPHROLOGY» , vol. 32 , n. 2 , 2019 , pp. 323-330

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