Publications

Authors:

Ferrarini, Isacco; Rigo, Antonella; Zamò, Alberto; Vinante, Fabrizio

Title:

Classical Hodgkin lymphoma cells may promote an IL-17-enriched microenvironment

Year:

2019

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

No

Name of journal:

Leukemia and Lymphoma

ISSN of journal:

1042-8194

Page numbers:

1-11

Keyword:

CD30; Interleukin 17; T helper lymphocytes; classical Hodgkin lymphoma; microenvironment

Short description of contents:

In classical Hodgkin lymphoma (cHL), the significance of the interplay between Hodgkin and Reed-Sternberg cells (HRS) and reactive T cells remains poorly defined. By immunohistochemistry on bioptic cHL specimens, we found that HRS and surrounding T lymphocytes stained positive for IL-17 in 40% of cases. IL-17 was detectable in a similar proportion of patients' sera and correlated with disease burden. Supernatants of KM-H2 and HDLM-2 cHL cell lines guided preferential chemotaxis of CCR6(+) T lymphocytes. Coculture of cHL cell lines with PBMC promoted the enrichment of Th17 lymphocytes and Foxp3(+)/IL-17(+) cells, whereas T regulatory cells slightly decreased. Soluble CD30 downmodulated membrane CD30 expression on T cells and contributed to their polarization shift by stimulating IL-17 production and reducing IFN-gamma synthesis. Thus, HRS and a number of reactive CD4(+) T cells, attracted by tumor-secreted chemokines, produce an IL-17 tumor-shaped inflammatory milieu in a cHL subset.

Product ID:

109975

Handle IRIS:

11562/999250

Last Modified:

November 15, 2022

Bibliographic citation:

Ferrarini, Isacco; Rigo, Antonella; Zamò, Alberto; Vinante, Fabrizio, Classical Hodgkin lymphoma cells may promote an IL-17-enriched microenvironment «Leukemia and Lymphoma» , 2019 , pp. 1-11

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