Publications

Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study  (2020)

Authors:
ACCORDINI, Simone; Calciano, Lucia; MARCON, Alessandro; Pesce, Giancarlo; M Antó, Josep; B Beckmeyer-Borowko, Anna; Carsin, Anne-Elie; Corsico, Angelo Guido; Imboden, Medea; Janson, Christer; Keidel, Dirk; LOCATELLI, Francesca; Svanes, Cecilie; GJ Burney, Peter; Jarvis, Deborah; M Probst-Hensch, Nicole; Minelli, Cosetta
Title:
Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study
Year:
2020
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
Elettronico
Referee:
Name of journal:
SCIENTIFIC REPORTS
ISSN of journal:
2045-2322
N° Volume:
10
Number or Folder:
1
Page numbers:
1-9
Keyword:
Ageing Lungs in European Cohorts (ALEC) Study, airflow obstruction, cohort study, European Community Respiratory Health Survey (ECRHS), incidence, Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA), tobacco smoking, trend
Short description of contents:
Investigating COPD trends may help healthcare providers to forecast future disease burden. We estimated sex- and smoking-specific incidence trends of pre-bronchodilator airflow obstruction (AO) among adults without asthma from 11 European countries within a 20-year follow-up (ECRHS and SAPALDIA cohorts). We also quantified the extent of misclassification in the definition based on pre-bronchodilator spirometry (using post-bronchodilator measurements from a subsample of subjects) and we used this information to estimate the incidence of post-bronchodilator AO (AOpost-BD), which is the primary characteristic of COPD. AO incidence was 4.4 (95%CI: 3.5-5.3) male and 3.8 (3.1-4.6) female cases/1,000/year. Among ever smokers (median pack-years: 20, males; 12, females), AO incidence significantly increased with ageing in men only [incidence rate ratio (IRR), 1-year increase: 1.05 (1.03-1.07)]. A strong exposure-response relationship with smoking was found both in males [IRR, 1-pack-year increase: 1.03 (1.02-1.04)] and females [1.03 (1.02-1.05)]. The positive predictive value of AO for AOpost-BD was 59.1% (52.0-66.2%) in men and 42.6% (35.1-50.1%) in women. AOpost-BD incidence was 2.6 (1.7-3.4) male and 1.6 (1.0-2.2) female cases/1,000/year. AO incidence was considerable in Europe and the sex-specific ageing-related increase among ever smokers was strongly related to cumulative tobacco exposure. AOpost-BD incidence is expected to be half of AO incidence.
Web page:
https://rdcu.be/b2cY2
Product ID:
113083
Handle IRIS:
11562/1012426
Last Modified:
June 30, 2020
Bibliographic citation:
ACCORDINI, Simone; Calciano, Lucia; MARCON, Alessandro; Pesce, Giancarlo; M Antó, Josep; B Beckmeyer-Borowko, Anna; Carsin, Anne-Elie; Corsico, Angelo Guido; Imboden, Medea; Janson, Christer; Keidel, Dirk; LOCATELLI, Francesca; Svanes, Cecilie; GJ Burney, Peter; Jarvis, Deborah; M Probst-Hensch, Nicole; Minelli, Cosetta, Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study «SCIENTIFIC REPORTS» , vol. 10 , n. 12020pp. 1-9

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Title Department Managers
Ageing Lungs in European Cohorts (ALEC) Study Department Diagnostica e Sanità Pubblica Simone Accordini
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