Publications

Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?  (2020)

Authors:
Johannessen, A; Lønnebotn, M; Calciano, L; Benediktsdóttir, B; Bertelsen, RJ; Bråbäck, L; Dharmage, S; Franklin, KA; Gislason, T; Holm, M; Janson, C; Jarvis, D; Jõgi, R; Kim, JL; Kirkeleit, J; Lodge, C; Malinovschi, A; Martinez-Moratalla, J; Nilsen, RM; Pereira-Vega, A; Real, FG; Schlünssen, V; Accordini, S; Svanes, C
Title:
Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation?
Year:
2020
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
Journal of Allergy and Clinical Immunonology
ISSN of journal:
0091-6749
N° Volume:
145
Number or Folder:
3
:
Elsevier Science
Page numbers:
791-799
Keyword:
Ageing Lungs in European Cohorts study, epidemiology, multilevel mediation model, offspring, parental risk factors
Short description of contents:
BACKGROUND: Overweight status and asthma have increased during the last decades. Being overweight is a known risk factor for asthma, but it is not known whether it might also increase asthma risk in the next generation. OBJECTIVE: We aimed to examine whether parents being overweight in childhood, adolescence, or adulthood is associated with asthma in their offspring. METHODS: We included 6347 adult offspring (age, 18-52 years) investigated in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) multigeneration study of 2044 fathers and 2549 mothers (age, 37-66 years) investigated in the European Community Respiratory Health Survey (ECRHS) study. Associations of parental overweight status at age 8 years, puberty, and age 30 years with offspring's childhood overweight status (potential mediator) and offspring's asthma with or without nasal allergies (outcomes) was analyzed by using 2-level logistic regression and 2-level multinomial logistic regression, respectively. Counterfactual-based mediation analysis was performed to establish whether observed associations were direct or indirect effects mediated through the offspring's own overweight status. RESULTS: We found statistically significant associations between both fathers' and mothers' childhood overweight status and offspring's childhood overweight status (odds ratio, 2.23 [95% CI, 1.45-3.42] and 2.45 [95% CI, 1.86-3.22], respectively). We also found a statistically significant effect of fathers' onset of being overweight in puberty on offspring's asthma without nasal allergies (relative risk ratio, 2.31 [95% CI, 1.23-4.33]). This effect was direct and not mediated through the offspring's own overweight status. No effect on offspring's asthma with nasal allergies was found. CONCLUSION: Our findings suggest that metabolic factors long before conception can increase asthma risk and that male puberty is a time window of particular importance for offspring's health.
Product ID:
113111
Handle IRIS:
11562/1012457
Last Modified:
June 30, 2020
Bibliographic citation:
Johannessen, A; Lønnebotn, M; Calciano, L; Benediktsdóttir, B; Bertelsen, RJ; Bråbäck, L; Dharmage, S; Franklin, KA; Gislason, T; Holm, M; Janson, C; Jarvis, D; Jõgi, R; Kim, JL; Kirkeleit, J; Lodge, C; Malinovschi, A; Martinez-Moratalla, J; Nilsen, RM; Pereira-Vega, A; Real, FG; Schlünssen, V; Accordini, S; Svanes, C, Being overweight in childhood, puberty, or early adulthood: Changing asthma risk in the next generation? «Journal of Allergy and Clinical Immunonology» , vol. 145 , n. 32020pp. 791-799

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Ageing Lungs in European Cohorts (ALEC) Study Department Diagnostica e Sanità Pubblica Simone Accordini
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