Pubblicazioni

Autori:

Tomaiuolo, L.; Geraci, L.; Longo, C.; Todesco, M.; Autelitano, D.; Carli, A.; Cicalo’, F.; Moro, F.; De Robertis, R.; Cardobi, N.; D'Onofrio, Mirko

Titolo:

Evaluation of liver injury with MRI after chemotherapy

Anno:

2022

Tipologia prodotto:

Abstract in Atti di convegno

Tipologia ANVUR:

Abstract in Atti di convegno

Lingua:

Inglese

Titolo del Convegno:

ESGAR 2022

Luogo:

Lisbona (Portogallo)

Periodo:

31/5/2022 - 3/6/2022

Intervallo pagine:

34-34

Parole chiave:

liver, chemotherapy, magnetic resonance imaging

Breve descrizione dei contenuti:

Purpose: The aim of the study is to evaluate long-term liver injuries as sinusoidal obstruction syndrome (SOS) and chemotherapy-associated steatohepatitis (CASH) with functional MRI in patients with pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant chemotherapy. Material and Methods: In this prospective study, 10 patients with borderline resectable/locally advanced PDAC underwent a MRI at 1.5T including gradient echo sequence (T2-FFE) before and after 12 weeks from the beginning of neoadjuvant chemotherapy (liposomal irinotecan + fluorouracil/leucovorin + oxaliplatin). Clinical parameters as body mass index, history of diabetes, hypertension and biological parameters including bilirubin levels, AST, ALT, GGT and drug administration dosage were recorded. A single region of interest (ROI) including the whole liver and other 10 ROIs for hepatic segments were reproduced obtaining a T2* mapping for each patient before and after treatment. T2* values were measured and compared with Wilcoxon test. Results: Significant decrease of T2* values was observed after treatment (p < 0.05), demonstrating a lower hepatic oxygenation, especially for II, VII and VIII hepatic segments. For each patient, III segment T2* values were stable. In 3 patients, no significant changes of T2* values were recorded before and after chemotherapy. Conclusion: Liver steatosis and fibrosis interpose with sinusoidal patency. Including T2* mapping in liver MRI protocol may supply estimation of liver functional changes after chemotherapy.

Id prodotto:

129749

Handle IRIS:

11562/1075281

ultima modifica:

23 febbraio 2023

Citazione bibliografica:

Tomaiuolo, L.; Geraci, L.; Longo, C.; Todesco, M.; Autelitano, D.; Carli, A.; Cicalo’, F.; Moro, F.; De Robertis, R.; Cardobi, N.; D'Onofrio, Mirko, Evaluation of liver injury with MRI after chemotherapy  in Insights into Imaging , Atti di "ESGAR 2022" , Lisbona (Portogallo) , 31/5/2022 - 3/6/2022 , 2022 , pp. 34-34

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