Pubblicazioni

Autori:

Grillo, Federica; Angerilli, Valentina; Parente, Paola; Vanoli, Alessandro; Luchini, Claudio; Sciallero, Stefania; Puccini, Alberto; Bergamo, Francesca; Lonardi, Sara; Valeri, Nicola; Mastracci, Luca; Fassan, Matteo

Titolo:

Prevalence and type of MMR expression heterogeneity in colorectal adenocarcinoma: therapeutic implications and reporting

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

VIRCHOWS ARCHIV

ISSN Rivista:

0945-6317

N° Volume:

485

Numero o Fascicolo:

1

Editore:

Springer Verlag Germany:Tiergartenstrasse 17, D 69121 Heidelberg Germany:011 49 6221 3450, EMAIL: g.braun@springer.de, INTERNET: http://www.springer.de, Fax: 011 49 6221 345229

Intervallo pagine:

131-135

Parole chiave:

Colorectal adenocarcinoma; Immunohistochemistry; Immunotherapy; MMR; Heterogeneity

Breve descrizione dei contenuti:

Mismatch repair (MMR) immunohistochemical (IHC) evaluation has entered pathology routine practice as the first-line screening method to identify patients with MMR deficient (MMRd)/microsatellite instability (MSI) colorectal cancer (CRC), and its misdiagnosis may significantly impact the personalization of CRC patient care. To determine the prevalence of MMR protein intratumor heterogeneity in real-world practice, we collected a series of 8282 CRCs tested for MMR proteins in the setting of Lynch syndrome universal screening. Four heterogenous cases were also investigated for tumor infiltrating lymphocytes count, MSI status, and consensus molecular subtypes by Nanostring nCounter (R) Platform. Overall, 1056 (12.8%) CRCs showed a MMR altered status, with 46 cases showing a heterogeneous MMR profile (0.56% of the total, and 4.36% of all MMRd cases). To conclude, the authors make some critical remarks regarding the approach to MMR heterogeneity in clinical practice and routine diagnostics.

Note:

Epub 2023 Dec 23 Erratum in Correction to: Prevalence and type of MMR expression heterogeneity in colorectal adenocarcinoma: therapeutic implications and reporting. Grillo F, Angerilli V, Parente P, Vanoli A, Luchini C, Sciallero S, Puccini A, Bergamo F, Lonardi S, Valeri N, Mastracci L, Fassan M. Virchows Arch. 2024 Jan 17. doi: 10.1007/s00428-024-03733-8. Online ahead of print. PMID: 38231403 No abstract available

Id prodotto:

136979

Handle IRIS:

11562/1116786

ultima modifica:

24 luglio 2024

Citazione bibliografica:

Grillo, Federica; Angerilli, Valentina; Parente, Paola; Vanoli, Alessandro; Luchini, Claudio; Sciallero, Stefania; Puccini, Alberto; Bergamo, Francesca; Lonardi, Sara; Valeri, Nicola; Mastracci, Luca; Fassan, Matteo, Prevalence and type of MMR expression heterogeneity in colorectal adenocarcinoma: therapeutic implications and reporting «VIRCHOWS ARCHIV» , vol. 485 , n. 1 , 2024 , pp. 131-135

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo