Pubblicazioni

Autori:

Yuan, Yuan; Ju, Young Seok; Kim, Youngwook; Li, Jun; Wang, Yumeng; Yoon, Christopher J.; Yang, Yang; Martincorena, Inigo; Creighton, Chad J.; Weinstein, John N.; Xu, Yanxun; Han, Leng; Kim, Hyung-Lae; Nakagawa, Hidewaki; Park, Keunchil; Campbell, Peter J.; Liang, Han; Aaltonen, Lauri A.; Abascal, Federico; Abeshouse, Adam; Aburatani, Hiroyuki; Adams, David J.; Agrawal, Nishant; Ahn, Keun Soo; Ahn, Sung-Min; Aikata, Hiroshi; Akbani, Rehan; Akdemir, Kadir C.; Al-Ahmadie, Hikmat; Al-Sedairy, Sultan T.; Al-Shahrour, Fatima; Alawi, Malik; Albert, Monique; Aldape, Kenneth; Alexandrov, Ludmil B.; Ally, Adrian; Alsop, Kathryn; Alvarez, Eva G.; Amary, Fernanda; Amin, Samirkumar B.; Aminou, Brice; Ammerpohl, Ole; Anderson, Matthew J.; Ang, Yeng; Antonello, Davide; Anur, Pavana; Aparicio, Samuel; Appelbaum, Elizabeth L.; Arai, Yasuhito; Aretz, Axel; Arihiro, Koji; Ariizumi, Shun-ichi; Armenia, Joshua; Arnould, Laurent; Asa, Sylvia; Assenov, Yassen; Atwal, Gurnit; Aukema, Sietse; Auman, J. Todd; Aure, Miriam R. R.; Awadalla, Philip; Aymerich, Marta; Bader, Gary D.; Baez-Ortega, Adrian; Bailey, Matthew H.; Bailey, Peter J.; Balasundaram, Miruna; Balu, Saianand; Bandopadhayay, Pratiti; Banks, Rosamonde E.; Barbi, Stefano; Barbour, Andrew P.; Barenboim, Jonathan; Barnholtz-Sloan, Jill; Barr, Hugh; Barrera, Elisabet; Bartlett, John; Bartolome, Javier; Bassi, Claudio; Bathe, Oliver F.; Baumhoer, Daniel; Bavi, Prashant; Baylin, Stephen B.; Bazant, Wojciech; Beardsmore, Duncan; Beck, Timothy A.; Behjati, Sam; Behren, Andreas; Niu, Beifang; Bell, Cindy; Beltran, Sergi; Benz, Christopher; Berchuck, Andrew; Bergmann, Anke K.; Bergstrom, Erik N.; Berman, Benjamin P.; Berney, Daniel M.; Bernhart, Stephan H.; Beroukhim, Rameen; Berrios, Mario; Bersani, Samantha; Bertl, Johanna; Betancourt, Miguel; Bhandari, Vinayak; Bhosle, Shriram G.; Biankin, Andrew V.; Bieg, Matthias; Bigner, Darell; Binder, Hans; Birney, Ewan; Birrer, Michael; Biswas, Nidhan K.; Bjerkehagen, Bodil; Bodenheimer, Tom; Boice, Lori; Bonizzato, Giada; De Bono, Johann S.; Boot, Arnoud; Bootwalla, Moiz S.; Borg, Ake; Borkhardt, Arndt; Boroevich, Keith A.; Borozan, Ivan; Borst, Christoph; Bosenberg, Marcus; Bosio, Mattia; Boultwood, Jacqueline; Bourque, Guillaume; Boutros, Paul C.; Bova, G. Steven; Bowen, David T.; Bowlby, Reanne; Bowtell, David D. L.; Boyault, Sandrine; Boyce, Rich; Boyd, Jeffrey; Brazma, Alvis; Brennan, Paul; Brewer, Daniel S.; Brinkman, Arie B.; Bristow, Robert G.; Broaddus, Russell R.; Brock, Jane E.; Brock, Malcolm; Broeks, Annegien; Brooks, Angela N.; Brooks, Denise; Brors, Benedikt; Brunak, Søren; Bruxner, Timothy J. C.; Bruzos, Alicia L.; Buchanan, Alex; Buchhalter, Ivo; Buchholz, Christiane; Bullman, Susan; Burke, Hazel; Burkhardt, Birgit; Burns, Kathleen H.; Busanovich, John; Bustamante, Carlos D.; Butler, Adam P.; Butte, Atul J.; Byrne, Niall J.; Børresen-Dale, Anne-Lise; Caesar-Johnson, Samantha J.; Cafferkey, Andy; Cahill, Declan; Calabrese, Claudia; Caldas, Carlos; Calvo, Fabien; Camacho, Niedzica; Campbell, Peter J.; Campo, Elias; Cantù, Cinzia; Cao, Shaolong; Carey, Thomas E.; Carlevaro-Fita, Joana; Carlsen, Rebecca; Cataldo, Ivana; Cazzola, Mario; Cebon, Jonathan; Cerfolio, Robert; Chadwick, Dianne E.; Chakravarty, Dimple; Chalmers, Don; Chan, Calvin Wing Yiu; Chan, Kin; Chan-Seng-Yue, Michelle; Chandan, Vishal S.; Chang, David K.; Chanock, Stephen J.; Chantrill, Lorraine A.; Chateigner, Aurélien; Chatterjee, Nilanjan; Chayama, Kazuaki; Chen, Hsiao-Wei; Chen, Jieming; Chen, Ken; Chen, Yiwen; Chen, Zhaohong; Cherniack, Andrew D.; Chien, Jeremy; Chiew, Yoke-Eng; Chin, Suet-Feung; Cho, Juok; Cho, Sunghoon; Choi, Jung Kyoon; Choi, Wan; Chomienne, Christine; Chong, Zechen; Choo, Su Pin; Chou, Angela; Christ, Angelika N.; Christie, Elizabeth L.; Chuah, Eric; Cibulskis, Carrie; Cibulskis, Kristian; Cingarlini, Sara; Clapham, Peter; Claviez, Alexander; Cleary, Sean; Cloonan, Nicole; Cmero, Marek; Collins, Colin C.

Titolo:

Comprehensive molecular characterization of mitochondrial genomes in human cancers

Anno:

2020

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Nature Genetics

ISSN Rivista:

1061-4036

N° Volume:

52

Numero o Fascicolo:

3

Intervallo pagine:

342-352

Parole chiave:

cancer, molecular characterization, mitochrondrial

Breve descrizione dei contenuti:

: Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we performed a multidimensional, integrated characterization of mitochondrial genomes and related RNA sequencing data. Our analysis presents the most definitive mutational landscape of mitochondrial genomes and identifies several hypermutated cases. Truncating mutations are markedly enriched in kidney, colorectal and thyroid cancers, suggesting oncogenic effects with the activation of signaling pathways. We find frequent somatic nuclear transfers of mitochondrial DNA, some of which disrupt therapeutic target genes. Mitochondrial copy number varies greatly within and across cancers and correlates with clinical variables. Co-expression analysis highlights the function of mitochondrial genes in oxidative phosphorylation, DNA repair and the cell cycle, and shows their connections with clinically actionable genes. Our study lays a foundation for translating mitochondrial biology into clinical applications.

Note:

Supplementary information is available for this paper a https://doi.org/10.1038/s41588-019-0557-x

Id prodotto:

137798

Handle IRIS:

11562/1119517

ultima modifica:

2 febbraio 2025

Citazione bibliografica:

Yuan, Yuan; Ju, Young Seok; Kim, Youngwook; Li, Jun; Wang, Yumeng; Yoon, Christopher J.; Yang, Yang; Martincorena, Inigo; Creighton, Chad J.; Weinstein, John N.; Xu, Yanxun; Han, Leng; Kim, Hyung-Lae; Nakagawa, Hidewaki; Park, Keunchil; Campbell, Peter J.; Liang, Han; Aaltonen, Lauri A.; Abascal, Federico; Abeshouse, Adam; Aburatani, Hiroyuki; Adams, David J.; Agrawal, Nishant; Ahn, Keun Soo; Ahn, Sung-Min; Aikata, Hiroshi; Akbani, Rehan; Akdemir, Kadir C.; Al-Ahmadie, Hikmat; Al-Sedairy, Sultan T.; Al-Shahrour, Fatima; Alawi, Malik; Albert, Monique; Aldape, Kenneth; Alexandrov, Ludmil B.; Ally, Adrian; Alsop, Kathryn; Alvarez, Eva G.; Amary, Fernanda; Amin, Samirkumar B.; Aminou, Brice; Ammerpohl, Ole; Anderson, Matthew J.; Ang, Yeng; Antonello, Davide; Anur, Pavana; Aparicio, Samuel; Appelbaum, Elizabeth L.; Arai, Yasuhito; Aretz, Axel; Arihiro, Koji; Ariizumi, Shun-ichi; Armenia, Joshua; Arnould, Laurent; Asa, Sylvia; Assenov, Yassen; Atwal, Gurnit; Aukema, Sietse; Auman, J. Todd; Aure, Miriam R. R.; Awadalla, Philip; Aymerich, Marta; Bader, Gary D.; Baez-Ortega, Adrian; Bailey, Matthew H.; Bailey, Peter J.; Balasundaram, Miruna; Balu, Saianand; Bandopadhayay, Pratiti; Banks, Rosamonde E.; Barbi, Stefano; Barbour, Andrew P.; Barenboim, Jonathan; Barnholtz-Sloan, Jill; Barr, Hugh; Barrera, Elisabet; Bartlett, John; Bartolome, Javier; Bassi, Claudio; Bathe, Oliver F.; Baumhoer, Daniel; Bavi, Prashant; Baylin, Stephen B.; Bazant, Wojciech; Beardsmore, Duncan; Beck, Timothy A.; Behjati, Sam; Behren, Andreas; Niu, Beifang; Bell, Cindy; Beltran, Sergi; Benz, Christopher; Berchuck, Andrew; Bergmann, Anke K.; Bergstrom, Erik N.; Berman, Benjamin P.; Berney, Daniel M.; Bernhart, Stephan H.; Beroukhim, Rameen; Berrios, Mario; Bersani, Samantha; Bertl, Johanna; Betancourt, Miguel; Bhandari, Vinayak; Bhosle, Shriram G.; Biankin, Andrew V.; Bieg, Matthias; Bigner, Darell; Binder, Hans; Birney, Ewan; Birrer, Michael; Biswas, Nidhan K.; Bjerkehagen, Bodil; Bodenheimer, Tom; Boice, Lori; Bonizzato, Giada; De Bono, Johann S.; Boot, Arnoud; Bootwalla, Moiz S.; Borg, Ake; Borkhardt, Arndt; Boroevich, Keith A.; Borozan, Ivan; Borst, Christoph; Bosenberg, Marcus; Bosio, Mattia; Boultwood, Jacqueline; Bourque, Guillaume; Boutros, Paul C.; Bova, G. Steven; Bowen, David T.; Bowlby, Reanne; Bowtell, David D. L.; Boyault, Sandrine; Boyce, Rich; Boyd, Jeffrey; Brazma, Alvis; Brennan, Paul; Brewer, Daniel S.; Brinkman, Arie B.; Bristow, Robert G.; Broaddus, Russell R.; Brock, Jane E.; Brock, Malcolm; Broeks, Annegien; Brooks, Angela N.; Brooks, Denise; Brors, Benedikt; Brunak, Søren; Bruxner, Timothy J. C.; Bruzos, Alicia L.; Buchanan, Alex; Buchhalter, Ivo; Buchholz, Christiane; Bullman, Susan; Burke, Hazel; Burkhardt, Birgit; Burns, Kathleen H.; Busanovich, John; Bustamante, Carlos D.; Butler, Adam P.; Butte, Atul J.; Byrne, Niall J.; Børresen-Dale, Anne-Lise; Caesar-Johnson, Samantha J.; Cafferkey, Andy; Cahill, Declan; Calabrese, Claudia; Caldas, Carlos; Calvo, Fabien; Camacho, Niedzica; Campbell, Peter J.; Campo, Elias; Cantù, Cinzia; Cao, Shaolong; Carey, Thomas E.; Carlevaro-Fita, Joana; Carlsen, Rebecca; Cataldo, Ivana; Cazzola, Mario; Cebon, Jonathan; Cerfolio, Robert; Chadwick, Dianne E.; Chakravarty, Dimple; Chalmers, Don; Chan, Calvin Wing Yiu; Chan, Kin; Chan-Seng-Yue, Michelle; Chandan, Vishal S.; Chang, David K.; Chanock, Stephen J.; Chantrill, Lorraine A.; Chateigner, Aurélien; Chatterjee, Nilanjan; Chayama, Kazuaki; Chen, Hsiao-Wei; Chen, Jieming; Chen, Ken; Chen, Yiwen; Chen, Zhaohong; Cherniack, Andrew D.; Chien, Jeremy; Chiew, Yoke-Eng; Chin, Suet-Feung; Cho, Juok; Cho, Sunghoon; Choi, Jung Kyoon; Choi, Wan; Chomienne, Christine; Chong, Zechen; Choo, Su Pin; Chou, Angela; Christ, Angelika N.; Christie, Elizabeth L.; Chuah, Eric; Cibulskis, Carrie; Cibulskis, Kristian; Cingarlini, Sara; Clapham, Peter; Claviez, Alexander; Cleary, Sean; Cloonan, Nicole; Cmero, Marek; Collins, Colin C., Comprehensive molecular characterization of mitochondrial genomes in human cancers «Nature Genetics» , vol. 52 , n. 3 , 2020 , pp. 342-352

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