Pubblicazioni

Autori:

Tängdén, Thomas; Carrara, Elena; Hellou, Mona Mustafa; Yahav, Dafna; Paul, Mical

Titolo:

Introducing new antibiotics for multidrug-resistant bacteria: obstacles and the way forward

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Clinical Microbiology and Infection

ISSN Rivista:

1198-743X

N° Volume:

31

Numero o Fascicolo:

3

Intervallo pagine:

354-359

Parole chiave:

Antimicrobial stewardship; Availability; Clinical evidence; New antibiotics; Reimbursement; Treatment guidelines; resistance development

Breve descrizione dei contenuti:

Background: Following intense efforts to revive the dry antibiotic research and development pipeline, a few highly awaited antibiotics with activity against multidrug-resistant (MDR) bacteria were recently approved. Objectives: We aim to highlight gaps in the evidence generated for new antibiotics by the time of their approval and to review the consequent limitations of treatment guidelines for priority MDR bacteria. We also report on availability of the new antibiotics, reimbursement strategies allowing use of these antibiotics in hospitals and antibiotic stewardship efforts. Sources: We searched PubMed for phase 3 randomized controlled trials that assessed antibiotics approved for use against MDR bacteria between 2013-2023. Other sources included governmental and professional documents regarding policies for reimbursement and use of the new antibiotics. Content: Several gaps in the evidence available regarding the new antibiotics are described related to the trials' target populations, comparators, management algorithm within the trial, non-inferiority hypotheses and assessment of resistance development within the studies. We highlight the risk of current guidelines to increase usage of new antibiotics and consequently accelerate resistance development. Updated mapping of antibiotic availability reveals critical inequality in access to the new antibiotics. Finally, strategies used nationally in Europe to provide access to the new antibiotics are not sufficiently balanced by antibiotic stewardship efforts to calibrate judicious use of the new antibiotics. Implications: Antibiotic resistance is an immediate threat. The present review highlights areas where more systematic and uniform strategies across countries and geographical regions are warranted to improve evidence, availability and use of new broad-spectrum antibiotics.

Note:

Epub 2024 Oct 5

Id prodotto:

141610

Handle IRIS:

11562/1141406

ultima modifica:

13 marzo 2025

Citazione bibliografica:

Tängdén, Thomas; Carrara, Elena; Hellou, Mona Mustafa; Yahav, Dafna; Paul, Mical, Introducing new antibiotics for multidrug-resistant bacteria: obstacles and the way forward «Clinical Microbiology and Infection» , vol. 31 , n. 3 , 2025 , pp. 354-359

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