Pubblicazioni

Autori:

Tazza, Beatrice; Caroccia, Natascia; Toschi, Alice; Pascale, Renato; Gkrania-Klotsas, Effrosyni; Navarro, Paula Olivares; Canziani, Lorenzo Maria; Tavelli, Alessandro; Antinori, Andrea; Grossi, Paolo Antonio; Peghin, Maddalena; Tacconelli, Evelina; Palacios-Baena, Zaira Raquel; Viale, Pierluigi; Giannella, Maddalena; Expert Team Group Authorship, Collaborators In Expert Team And Orchestra Wp4 Working Group.; Wp4 Working Group, ; Pierrotti, Ligia; Manuel, Oriol; Mularoni, Alessandra; Avery, Robin; Paniagua, Maria; Bartoletti, Michele; Carbone, Javier; Valerio, Maricela; Mueller, Nicolas; Los-Arcos, Ibai; Bodro, Marta; Gkrania-Klotsas, Effrossyni; Graziano, Elena; Maria Luisa Balsamo, ; Rinaldi, Matteo; Pascale, Renato; Bonazzetti, Cecilia; Giannella, Maddalena; Tazza, Beatrice; Grossi, Paolo; Peghin, Maddalena; Addis, Elena; Azzini, Anna; Virginia Almadana Pacheco, ; Maria Giulia Caponcello, ; Carrara, Elena; Cataudella, Salvatore; Camici, Marta; Cascio, Antonio; Comai, Giorgia; Cozzi-Lepri, Alessandro; Dellacasa, Chiara; Antonella D'Arminio Monforte, ; Gabrielli, Liliana; Gentilotti, Elisa; Gibertoni, Dino; Lazzarotto, Tiziana; López, Inmaculada; Maccarrone, Gaia; Madeddu, Giordano; Mazzaferri, Fulvia; Maria Cristina Morelli, ; Pellicanò, Giovanni; Patricia Pérez Palacios, ; Piconi, Stefania; Potena, Luciano; Rodanò, Alessandra; Jesús Rodríguez Baño, ; Rossi, Elisa; Sangiovanni, Nadia; Salvaterra, Elena; Santoro, Andrea; Visentin, Alessandro

Titolo:

ORCHESTRA Delphi Consensus: Diagnostic and Therapeutic Management of SARS-CoV-2 Infection in Solid Organ Transplant Recipients

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Clinical Microbiology and Infection

ISSN Rivista:

1198-743X

N° Volume:

31

Numero o Fascicolo:

8S

Intervallo pagine:

S3-S13

Parole chiave:

COVID-19; Delphi; SOT; consensus; diagnosis; risk of progression; treatment

Breve descrizione dei contenuti:

Objectives: Our aim was to address existing knowledge gaps regarding risk stratification, best use of diagnostic resources, optimal treatment and general management of SARS-CoV-2 infection in solid organ transplant (SOT) recipients. As high-quality evidence specific to this fragile population is lacking, our final aim was to provide an expert consensus evidence-informed guidance that can aid clinicians in their daily practice. Methods: This study was conducted within the Working Package 4 (WP4 - Fragile population cohorts) of the H2020 funded ORCHESTRA study [https://orchestra-cohort.eu]. Eight infectious disease and one clinical pharmacology specialists conducted a comprehensive scoping literature review which covered five key areas: the role of SOT as a risk factor for evolution to severe disease; the optimal use of diagnostic resources, considering cost-benefit ratios and appropriateness of active screening; a population-specific therapeutic management, including antiviral use and drug-drug interactions and appropriate duration of treatment; the potential need for withdrawal of immunosuppressive agents and management of potential donors and recipients with recent and/or ongoing SARS-CoV-2 infection at the time of transplantation. Based on this review, a 28-item questionnaire was developed and administered to a panel of experts through two rounds, following the Delphi methodology. Results: The panel consisted of 21 experts, 13 females and 8 males, from Italy (n=11), Spain (n=5), Switzerland (n=2), Brazil (n=1), United States (n=1), and United Kingdom (n=1). Consensus was achieved for 18 out of 28 items after the first round and for 9 out of 13 items after the second round, according with agreement/disagreement levels obtained for each question and round, ten statements were finally produced. Conclusions: The consensus statements derived from this study offer a framework for standardizing care and improving outcomes in SOT recipients affected by SARS-CoV-2 infection in field where high-quality evidence specific to this high-risk population is currently lacking.

Note:

Epub 2025 Feb 13

Id prodotto:

144354

Handle IRIS:

11562/1154990

ultima modifica:

22 agosto 2025

Citazione bibliografica:

Tazza, Beatrice; Caroccia, Natascia; Toschi, Alice; Pascale, Renato; Gkrania-Klotsas, Effrosyni; Navarro, Paula Olivares; Canziani, Lorenzo Maria; Tavelli, Alessandro; Antinori, Andrea; Grossi, Paolo Antonio; Peghin, Maddalena; Tacconelli, Evelina; Palacios-Baena, Zaira Raquel; Viale, Pierluigi; Giannella, Maddalena; Expert Team Group Authorship, Collaborators In Expert Team And Orchestra Wp4 Working Group.; Wp4 Working Group, ; Pierrotti, Ligia; Manuel, Oriol; Mularoni, Alessandra; Avery, Robin; Paniagua, Maria; Bartoletti, Michele; Carbone, Javier; Valerio, Maricela; Mueller, Nicolas; Los-Arcos, Ibai; Bodro, Marta; Gkrania-Klotsas, Effrossyni; Graziano, Elena; Maria Luisa Balsamo, ; Rinaldi, Matteo; Pascale, Renato; Bonazzetti, Cecilia; Giannella, Maddalena; Tazza, Beatrice; Grossi, Paolo; Peghin, Maddalena; Addis, Elena; Azzini, Anna; Virginia Almadana Pacheco, ; Maria Giulia Caponcello, ; Carrara, Elena; Cataudella, Salvatore; Camici, Marta; Cascio, Antonio; Comai, Giorgia; Cozzi-Lepri, Alessandro; Dellacasa, Chiara; Antonella D'Arminio Monforte, ; Gabrielli, Liliana; Gentilotti, Elisa; Gibertoni, Dino; Lazzarotto, Tiziana; López, Inmaculada; Maccarrone, Gaia; Madeddu, Giordano; Mazzaferri, Fulvia; Maria Cristina Morelli, ; Pellicanò, Giovanni; Patricia Pérez Palacios, ; Piconi, Stefania; Potena, Luciano; Rodanò, Alessandra; Jesús Rodríguez Baño, ; Rossi, Elisa; Sangiovanni, Nadia; Salvaterra, Elena; Santoro, Andrea; Visentin, Alessandro, ORCHESTRA Delphi Consensus: Diagnostic and Therapeutic Management of SARS-CoV-2 Infection in Solid Organ Transplant Recipients «Clinical Microbiology and Infection» , vol. 31 , n. 8S , 2025 , pp. S3-S13

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