Pubblicazioni

Autori:

Mirian, Christian; Jensen, Lasse Rehné; Hoffmann, Adam Gorm; Juratli, Tareq A; Maier, Andrea Daniela; Lindner, Pernilla; Broechner, Anders; Torp, Sverre H; Shih, Helen A; Morshed, Ramin A; Young, Jacob S; Magill, Stephen T; Stummer, Walter; Spille, Dorothee Cäcilia; Brokinkel, Benjamin; Proescholdt, Martin; Kuroi, Yasuhiro; Gousias, Konstantinos; Simon, Matthias; Prat-Acin, Ricardo; Goutagny, Stéphane; Wach, Johannes; Güresir, Erdem; Yamamoto, Junkoh; Kim, Young Zoon; Lee, Joo Ho; Kim, Daniel W; Koshy, Matthew; Cannon, Donald M; Shrieve, Dennis C; Suh, Chang-Ok; Chang, Jong Hee; Kamenova, Maria; Straumann, Sven; Soleman, Jehuda; Eyüpoglu, Ilker Y; Catalan, Tony; Lui, Austin; Theodosopoulos, Philip V; Mcdermott, Michael W; Góes, Pedro; Wang, Fang; Souhami, Luis; Guiot, Marie-Christine; Csonka, Tamás; Endo, Toshiki; Gupta, Tejpal; Patel, Akash J; Klisch, Tiemo J; Kim, Jun Won; Maiuri, Francesco; Barresi, Valeria; Tabernero, María Dolores; Skyrman, Simon; Krause, Mechthild; Law, Ian; Kristensen, Bjarne Winther; Munch, Tina Nørgaard; Meling, Torstein; Fugleholm, Kåre; Blanche, Paul; Mathiesen, Tiit

Titolo:

Fractionated radiotherapy adjuvant to surgery of WHO-2 meningioma with and without gross total resection: a multicenter, retrospective cohort study of 1,452 patients

Anno:

2026

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

Journal of Neuro Oncology

ISSN Rivista:

0167-594X

N° Volume:

176

Numero o Fascicolo:

3

Intervallo pagine:

1-13

Parole chiave:

Atypical meningioma; Meningioma; Progression; Radiotherapy; Recurrence; Resection

Breve descrizione dei contenuti:

Purpose: The role of adjuvant fractionated radiotherapy (aFRT) after gross total resection (GTR) of WHO-2 meningiomas remains unclear. We aimed to estimate the effect of aFRT on recurrence risk and survival following GTR and subtotal resection (STR). Methods: We analyzed 1452 patients with WHO-2 from our international, multicenter database (followed between 1989 and 2019). Outcomes were recurrence (10-year follow-up) and death (5-year follow-up). Risk estimates were obtained using competing risks and survival analysis. Average treatment effects were estimated by G-computation, adjusted for potential confounding by age, sex, Simpson grade, Ki-67 proliferation index, location, country group (universal healthcare or not), and year of treatment initiation. The robustness of findings was examined through sensitivity analyses. Results: Overall, 276 of 1452 patients (19.0%) received aFRT. Among GTR patients, unadjusted analysis showed comparable recurrence proportions between irradiated and non-irradiated patients (25.5% vs. 22.8% within 5 years). Adjusted analyses provided no evidence that aFRT reduced the risk of recurrence (largest difference: −2.7%, 95% CI −5.6 to 0.2); although, the CIs include the possibility of small beneficial effects. In STR patients, aFRT was associated with reduced recurrence risk in both unadjusted and adjusted analyses. Unexpectedly, a higher mortality was observed among irradiated GTR patients, largely driven by older patients with low Ki-67 PI receiving aFRT. Sensitivity analyses showed similar results for patients with STR but discrepancy in estimates for those with GTR. Conclusion: Adjuvant FRT showed a consistent reduction in recurrence risk after STR while inconsistent recurrence risk estimates were observed for patients with GTR. The findings reflect efficacy of aFRT using real-world data without standardized guidelines. Supplementary information: The online version contains supplementary material available at 10.1007/s11060-025-05349-7.

Id prodotto:

149768

Handle IRIS:

11562/1182691

ultima modifica:

18 aprile 2026

Citazione bibliografica:

Mirian, Christian; Jensen, Lasse Rehné; Hoffmann, Adam Gorm; Juratli, Tareq A; Maier, Andrea Daniela; Lindner, Pernilla; Broechner, Anders; Torp, Sverre H; Shih, Helen A; Morshed, Ramin A; Young, Jacob S; Magill, Stephen T; Stummer, Walter; Spille, Dorothee Cäcilia; Brokinkel, Benjamin; Proescholdt, Martin; Kuroi, Yasuhiro; Gousias, Konstantinos; Simon, Matthias; Prat-Acin, Ricardo; Goutagny, Stéphane; Wach, Johannes; Güresir, Erdem; Yamamoto, Junkoh; Kim, Young Zoon; Lee, Joo Ho; Kim, Daniel W; Koshy, Matthew; Cannon, Donald M; Shrieve, Dennis C; Suh, Chang-Ok; Chang, Jong Hee; Kamenova, Maria; Straumann, Sven; Soleman, Jehuda; Eyüpoglu, Ilker Y; Catalan, Tony; Lui, Austin; Theodosopoulos, Philip V; Mcdermott, Michael W; Góes, Pedro; Wang, Fang; Souhami, Luis; Guiot, Marie-Christine; Csonka, Tamás; Endo, Toshiki; Gupta, Tejpal; Patel, Akash J; Klisch, Tiemo J; Kim, Jun Won; Maiuri, Francesco; Barresi, Valeria; Tabernero, María Dolores; Skyrman, Simon; Krause, Mechthild; Law, Ian; Kristensen, Bjarne Winther; Munch, Tina Nørgaard; Meling, Torstein; Fugleholm, Kåre; Blanche, Paul; Mathiesen, Tiit, Fractionated radiotherapy adjuvant to surgery of WHO-2 meningioma with and without gross total resection: a multicenter, retrospective cohort study of 1,452 patients «Journal of Neuro Oncology» , vol. 176 , n. 3 , 2026 , pp. 1-13

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