Publications

Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche  (2009)

Authors:
Bifari F.; Decimo I.; Chiamulera C.; Bersan E.; Malpeli G.; Johansson J.; Lisi V.; Bonetti B.; Fumagalli G.; Pizzolo G.; Krampera M.
Title:
Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche
Year:
2009
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Name of journal:
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
ISSN of journal:
1582-1838
N° Volume:
13
Number or Folder:
9B
Page numbers:
3195-3208
Keyword:
neural stem cells; leptomeninges; stem cell niche; neuronal differentiation
Short description of contents:
Abstract Stem cells capable of generating neural differentiated cells are recognized by the expression of nestin and reside in specific regions of the brain, namely hippocampus, subventricular zone (SVZ), and olfactory bulb. For other brain structures, such as leptomeninges, which contribute to the correct cortex development and functions, there is no evidence so far that they may contain stem/precursor cells. In this work, we show for the first time that nestin-positive cells are present in rat leptomeninges during development up to adulthood. The newly identified nestin-positive cells can be extracted and expanded in vitro both as neurospheres, displaying high similarity with SVZ-derived neural stem cells, and as homogeneous cell population with stem cell features. In vitro expanded stem cell population can differentiate with high efficiency into excitable cells with neuronal phenotype and morphology. Once injected into adult brain, these cells survive and differentiate into neurons, thus showing that their neuronal differentiation potential is operational also in vivo. In conclusion, our data provide evidence that a specific population of immature cells endowed of neuronal differentiation potential is resident in the leptomeninges throughout the life. As leptomemniges cover the entire central nervous system, these findings could have relevant implications for studies on cortical development and for regenerative medicine applied to neurological disorders.
Product ID:
48840
Handle IRIS:
11562/327452
Deposited On:
January 20, 2010
Last Modified:
August 16, 2021
Attachments:
1
Bibliographic citation:
Bifari F.; Decimo I.; Chiamulera C.; Bersan E.; Malpeli G.; Johansson J.; Lisi V.; Bonetti B.; Fumagalli G.; Pizzolo G.; Krampera M., Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche «JOURNAL OF CELLULAR AND MOLECULAR MEDICINE» , vol. 13 , n. 9B2009pp. 3195-3208

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