Pubblicazioni

Autori:

Brunelli, Matteo; Manfrin, Erminia; Martignoni, Guido; Miller, K; Remo, Andrea; Reghellin, Daniela; Bersani, Samantha; Gobbo, Stefano; Eccher, Albino; Chilosi, Marco; Bonetti, Franco

Titolo:

Genotypic Intratumoral Heterogeneity in Breast Carcinoma with HER2/neu Amplification Evaluation According to ASCO/CAP Criteria

Anno:

2009

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

American Journal of Clinical Pathology

ISSN Rivista:

0002-9173

N° Volume:

131

Numero o Fascicolo:

5

Intervallo pagine:

678-682

Parole chiave:

breast cancer; Her-2; fluorescence in situ hybridization

Breve descrizione dei contenuti:

Abstract: We evaluated intratumoral heterogeneity of 30 ductal breast carcinomas with HER2/neu amplification, scored by the American Society of Clinical Oncology/ College of American Pathologists (ASCO/CAP) criteria, and 3+ immunoexpression. High-grade (ratio > or =4.0) vs low-grade amplification (ratio >2.2 to <4.0) and chromosome 17 polysomy were also evaluated. On whole tissue sections, 20 tumors (67%) showed high-grade and 10 (33%) showed low-grade HER2/ neu amplification. Of 20 tumors with high-grade amplification, 14 (70%) showed no intratumoral genotypic heterogeneity; 6 (30%) showed at least 1 core with low-grade amplification. Of 10 cases with low-grade amplification, 6 (60%) showed no intratumoral heterogeneity; 4 (40%) showed chromosome 17 polysomy without gene amplification in 2 of 3 cores per case. Of 30 cases with gene amplification, 4 (13%) showed a "not-amplified pattern" in other parts of the tumor. The routine assessment of HER2/neu amplification using the ASCO/CAP criteria on whole tissue sections is not significantly confounded by intratumoral heterogeneity in breast cancer with high-grade amplification; however, genetic heterogeneity exists in a subset of breast carcinomas with low-grade amplification. The clinical relevance and impact on treatment outcome of intratumoral heterogeneity in breast cancer with low-grade HER2/neu amplification or chromosome 17 polysomy need further investigation.

Note:

Pubblicazione nella rivista ufficiale della Società Americana di Oncologia Clinica. Numerose citazioni presso altre pubblicazioni di valore internazionale.

Id prodotto:

49764

Handle IRIS:

11562/328775

depositato il:

22 agosto 2009

ultima modifica:

27 novembre 2022

Citazione bibliografica:

Brunelli, Matteo; Manfrin, Erminia; Martignoni, Guido; Miller, K; Remo, Andrea; Reghellin, Daniela; Bersani, Samantha; Gobbo, Stefano; Eccher, Albino; Chilosi, Marco; Bonetti, Franco, Genotypic Intratumoral Heterogeneity in Breast Carcinoma with HER2/neu Amplification Evaluation According to ASCO/CAP Criteria «American Journal of Clinical Pathology» , vol. 131 , n. 5 , 2009 , pp. 678-682

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