Publications

Carbohydrate-deficient transferrin (CDT): Analytical and interpretative strategies  (2010)

Authors:
Bianchi V.; Pacifici R.; Palmi I.; Pichini S.; Vernocchi A.; Merlini G.; Ceriotti F.; Plebani M.; Tagliaro F.; Bernini M.; Bortolotti F.; Caligara M.; Cassandro P.; De Giovanni N.; Snenghi R.; Bertol E.
Title:
Carbohydrate-deficient transferrin (CDT): Analytical and interpretative strategies
Year:
2010
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Nations of authors:
ITALIA
Language:
Italiano
Format:
A Stampa
Referee:
Name of journal:
Biochimica Clinica
ISSN of journal:
0393-0564
N° Volume:
34
Number or Folder:
2
Page numbers:
128-138
Keyword:
Carbohydrate-deficient transferrin, CDT
Short description of contents:
This document presents a comprehensive overview of biochemistry and physiology of transferrin (Tf) and carbohydrate-deficient transferrin (CDT) and on the role of CDT as alcohol abuse marker. It discusses the characteristics of the available analytical methodologies for CDT determination and finally presents a set of recommendations. CDT measurements should be performed only in accredited laboratories, having a quality system in place and regularly performing IQC and participating in EQAS. Unequivocal patient identification and a documented chain of custody are needed. Non hemolysed serum is the preferred sample and, if it has to be stored for more than 8 h, freezing at -20°C is recommended. Immunological methods are acceptable only as first level testing. A confirmation of positive findings with analytical methods based on different physicochemical principles is recommended. The result should be expressed as percentage of disialo-Tf on total Tf. Each laboratory should establish its own decision limit based on the characteristics of the analytical method used and on the scope for which the measurement is performed. The employed analytical method should be indicated in the final report.
Product ID:
57733
Handle IRIS:
11562/345639
Deposited On:
October 20, 2010
Last Modified:
November 2, 2016
Bibliographic citation:
Bianchi V.; Pacifici R.; Palmi I.; Pichini S.; Vernocchi A.; Merlini G.; Ceriotti F.; Plebani M.; Tagliaro F.; Bernini M.; Bortolotti F.; Caligara M.; Cassandro P.; De Giovanni N.; Snenghi R.; Bertol E., Carbohydrate-deficient transferrin (CDT): Analytical and interpretative strategies «Biochimica Clinica» , vol. 34 , n. 22010pp. 128-138

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Studio e definizione dei range di normalità delle concentrazioni di CDT nel siero umano. Department Diagnostica e Sanità Pubblica Franco Tagliaro
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