Publications

Authors:

Carvajal, A.; Ortega, S.; Del Olmo, L.; Vidal, X.; Aguirre, C.; Ruiz, B; Conforti, Anita; Leone, Roberto; Lopez Vazquez, P.; Figueiras, A.; Ibanez, L.

Title:

Selective serotonin reuptake inhibitors and gastrointestinal bleeding: a case-control study

Year:

2011

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

PLoS ONE

ISSN of journal:

1932-6203

N° Volume:

6

Number or Folder:

5

Page numbers:

1-6

Keyword:

gastrointestinal bleeding; case-control; SSRIs

Short description of contents:

Background: Selective serotonin reuptake inhibitors (SSRIs) have been associated with upper gastrointestinal (GI) bleeding. Given their worldwide use, even small risks account for a large number of cases. This study has been conducted with carefully collected information to further investigate the relationship between SSRIs and upper GI bleeding. Methods: We conducted a case-control study in hospitals in Spain and in Italy. Cases were patients aged $18 years with a primary diagnosis of acute upper GI bleeding diagnosed by endoscopy; three controls were matched by sex, age, date of admission (within 3 months) and hospital among patients who were admitted for elective surgery for non-painful disorders. Exposures to SSRIs, other antidepressants and other drugs were defined as any use of these drugs in the 7 days before the day on which upper gastrointestinal bleeding started (index day). Results: 581 cases of upper GI bleeding and 1358 controls were considered eligible for the study; no differences in age or sex distribution were observed between cases and controls after matching. Overall, 4.0% of the cases and 3.3% of controls used an SSRI antidepressant in the week before the index day. No significant risk of upper GI bleeding was encountered for SSRI antidepressants (adjusted odds ratio, 1.06, 95% CI, 0.57–1.96) or for whichever other grouping of antidepressants. Conclusions: The results of this case-control study showed no significant increase in upper GI bleeding with SSRIs and provide good evidence that the magnitude of any increase in risk is not greater than 2.

Product ID:

61083

Handle IRIS:

11562/352595

Deposited On:

June 28, 2011

Last Modified:

November 15, 2022

Bibliographic citation:

Carvajal, A.; Ortega, S.; Del Olmo, L.; Vidal, X.; Aguirre, C.; Ruiz, B; Conforti, Anita; Leone, Roberto; Lopez Vazquez, P.; Figueiras, A.; Ibanez, L., Selective serotonin reuptake inhibitors and gastrointestinal bleeding: a case-control study «PLoS ONE» , vol. 6 , n. 5 , 2011 , pp. 1-6

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