- Authors:
-
Carvajal, A.; Ortega, S.; Del Olmo, L.; Vidal, X.; Aguirre, C.; Ruiz, B; Conforti, Anita; Leone, Roberto; Lopez Vazquez, P.; Figueiras, A.; Ibanez, L.
- Title:
-
Selective serotonin reuptake inhibitors and gastrointestinal bleeding: a case-control study
- Year:
-
2011
- Type of item:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Language:
-
Inglese
- Format:
-
Elettronico
- Referee:
-
Sì
- Name of journal:
- PLoS ONE
- ISSN of journal:
- 1932-6203
- N° Volume:
-
6
- Number or Folder:
-
5
- Page numbers:
-
1-6
- Keyword:
-
gastrointestinal bleeding; case-control; SSRIs
- Short description of contents:
- Background: Selective serotonin reuptake inhibitors (SSRIs) have been associated with upper gastrointestinal (GI) bleeding.
Given their worldwide use, even small risks account for a large number of cases. This study has been conducted with
carefully collected information to further investigate the relationship between SSRIs and upper GI bleeding.
Methods: We conducted a case-control study in hospitals in Spain and in Italy. Cases were patients aged $18 years with a
primary diagnosis of acute upper GI bleeding diagnosed by endoscopy; three controls were matched by sex, age, date of
admission (within 3 months) and hospital among patients who were admitted for elective surgery for non-painful disorders.
Exposures to SSRIs, other antidepressants and other drugs were defined as any use of these drugs in the 7 days before the
day on which upper gastrointestinal bleeding started (index day).
Results: 581 cases of upper GI bleeding and 1358 controls were considered eligible for the study; no differences in age or
sex distribution were observed between cases and controls after matching. Overall, 4.0% of the cases and 3.3% of controls
used an SSRI antidepressant in the week before the index day. No significant risk of upper GI bleeding was encountered for
SSRI antidepressants (adjusted odds ratio, 1.06, 95% CI, 0.57–1.96) or for whichever other grouping of antidepressants.
Conclusions: The results of this case-control study showed no significant increase in upper GI bleeding with SSRIs and
provide good evidence that the magnitude of any increase in risk is not greater than 2.
- Product ID:
-
61083
- Handle IRIS:
-
11562/352595
- Deposited On:
-
June 28, 2011
- Last Modified:
-
November 15, 2022
- Bibliographic citation:
-
Carvajal, A.; Ortega, S.; Del Olmo, L.; Vidal, X.; Aguirre, C.; Ruiz, B; Conforti, Anita; Leone, Roberto; Lopez Vazquez, P.; Figueiras, A.; Ibanez, L.,
Selective serotonin reuptake inhibitors and gastrointestinal bleeding: a case-control study
«PLoS ONE»
, vol.
6
, n.
5
,
2011
,
pp. 1-6
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