- Authors:
-
Di Trapani M;Bassi G;Ricciardi M;Fontana E;Bifari F;Pacelli L;Giacomello L;Pozzobon M;Féron F;De Coppi P;Anversa P;Fumagalli G;Decimo I;Menard C;Tarte K;Krampera M
- Title:
-
Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues.
- Year:
-
2013
- Type of item:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Language:
-
Inglese
- Format:
-
A Stampa
- Referee:
-
Sì
- Name of journal:
- STEM CELLS AND DEVELOPMENT
- ISSN of journal:
- 1547-3287
- N° Volume:
-
22
- Number or Folder:
-
22
- Page numbers:
-
1-13
- Keyword:
-
adult stem cells
- Short description of contents:
- Allogeneic stem cell-based therapy is a promising tool for the treatment of a range of human degenerative and inflammatory diseases. Many reports highlighted the immune modulatory properties of some stem cell (SC) types, such as mesenchymal stromal cells (MSCs), but a comparative study with SCs of different origin, to assess whether immune regulation is a general SC property, is still lacking. To this aim, we applied highly standardized methods employed for MSC characterization to compare the immunological properties of bone marrow-MSCs, olfactory ecto-mesenchymal stem cells, leptomeningeal stem cells, and three different c-Kit-positive SC types, i.e. amniotic fluid SCs, cardiac SCs, and lung SCs. We found that all the analyzed human SCs share a common pattern of immunological features, in terms of expression of activation markers ICAM-1, VCAM-1, HLA-ABC and HLA-DR, modulatory activity towards purified T, B and NK cells, lower immunogenicity of inflammatory-primed SCs as compared to resting SCs, and IDO-activation as molecular inhibitory pathways, with some SC type-related peculiarities. Moreover, the SC types analyzed exert an anti-apoptotic effect towards not-activated immune effector cells. In addition, we found that the inhibitory behavior is not a constitutive property of SCs, but is acquired as a consequence of immune effector cell activation, as previously described for MSCs. Thus, immune regulation is a general property of stem cells and the characterization of this phenomenon may be useful for a proper therapeutic use of SCs.
- Product ID:
-
77747
- Handle IRIS:
-
11562/614953
- Deposited On:
-
September 16, 2013
- Last Modified:
-
August 31, 2017
- Bibliographic citation:
-
Di Trapani M;Bassi G;Ricciardi M;Fontana E;Bifari F;Pacelli L;Giacomello L;Pozzobon M;Féron F;De Coppi P;Anversa P;Fumagalli G;Decimo I;Menard C;Tarte K;Krampera M,
Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues.
«STEM CELLS AND DEVELOPMENT»
, vol.
22
, n.
22
,
2013
,
pp. 1-13
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